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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc1tm1.2Tyj
targeted mutation 1.2, Tyler Jacks
MGI:3790968
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc1tm1.2Tyj/Mirc1tm1.2Tyj B6.Cg-Mirc1tm1.2Tyj MGI:5662394
hm2
 		Mirc1tm1.2Tyj/Mirc1tm1.2Tyj involves: 129S4/SvJae * C57BL/6 MGI:4941216
hm3
 		Mirc1tm1.2Tyj/Mirc1tm1.2Tyj involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796144
ht4
 		Mirc1tm1.2Tyj/Mirc1+ B6.Cg-Mirc1tm1.2Tyj MGI:5662393
ht5
 		Mirc1tm1.2Tyj/Mirc1+ involves: 129S4/SvJae * C57BL/6 MGI:5442701
ht6
 		Mirc1tm1.2Tyj/Mirc1+ involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796148
cn7
 		Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0 		involves: 129S4/SvJaeSor * C57BL/6 MGI:4941217
cx8
 		Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796151
cx9
 		Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796152
cx10
 		Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+ 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796153
cx11
 		Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3+
Mirc1tm1.2Tyj/Mirc1+ 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796428
cx12
 		Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+ 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796150


Genotype
MGI:5662394
hm1
Allelic
Composition		 Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 B6.Cg-Mirc1tm1.2Tyj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

digestive/alimentary system

embryo

growth/size/body
cleft palate ( J:223213 )

limbs/digits/tail
fused carpal bones ( J:223213 )
• all mice exhibit fusion of the proximal carpal bones
abnormal phalanx morphology ( J:223213 )
• the fifth mesophalanx of the forelimb is absent in E18.5 embryos
syndactyly ( J:223213 )
• toe syndactly

mortality/aging

skeleton
fused carpal bones ( J:223213 )
• all mice exhibit fusion of the proximal carpal bones
abnormal phalanx morphology ( J:223213 )
• the fifth mesophalanx of the forelimb is absent in E18.5 embryos
vertebral fusion ( J:223213 )
• all mice exhibit vertebral fusion
thoracic vertebral transformation ( J:223213 )
• vertebra 14 is transformed from last vertebra of the rib cage into first vertebra with floating ribs (T7 to T8)
• unilateral and bilateral loss of ribs on vertebra 20 (T13 to L1a)
lumbar vertebral transformation ( J:223213 )
• transformation of vertebra 26 from last lumbar to first sacral vertebra (L6 to S1)




Genotype
MGI:4941216
hm2
Allelic
Composition		 Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular septal defect ( J:169047 , J:223213 )
• ventricular septal defect observed in E18.5 embryos (J:223213)

mortality/aging

limbs/digits/tail
fused carpal bones ( J:188762 )
• E18.5 mutants exhibit fusion of the proximal carpal bones
abnormal phalanx morphology ( J:188762 )
• complete absence of the mesophalanx of the fifth digit is seen in E18.5 mutants
brachyphalangia ( J:188762 )
• E18.5 mutants exhibit the presence of a small mesophalanx of the second digit and hypoplasia of the first digital ray
abnormal forelimb zeugopod morphology ( J:188762 )
• E18.5 mutants exhibit dysmorphic zeugopods
abnormal hindlimb zeugopod morphology ( J:188762 )
• E18.5 mutants exhibit dysmorphic zeugopods

respiratory system

skeleton
fused carpal bones ( J:188762 )
• E18.5 mutants exhibit fusion of the proximal carpal bones
abnormal phalanx morphology ( J:188762 )
• complete absence of the mesophalanx of the fifth digit is seen in E18.5 mutants
brachyphalangia ( J:188762 )
• E18.5 mutants exhibit the presence of a small mesophalanx of the second digit and hypoplasia of the first digital ray
cervical vertebral fusion ( J:188762 )
• all E18.5 mutants exhibit fusion of the cervical vertebrae
delayed endochondral bone ossification ( J:188762 )
• E18.5 mutants exhibit a severe and general delay of endochondral ossification
delayed intramembranous bone ossification ( J:188762 )
• E18.5 mutants exhibit a severe and general delay of membranous ossification, with delayed ossification of occipital, parietal and frontal bones

growth/size/body
microcephaly ( J:188762 )
• seen in all E18.5 mutants




Genotype
MGI:3796144
hm3
Allelic
Composition		 Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:134861 )
• no viable homozygotes are produced from heterozygous intercrosses; homozygous phenotype is indistinguishable from Mirn17-92tm1.3Tyj homozygotes

embryo
decreased embryo size ( J:134861 )
• at E13.5, mutants can be distinguished by their smaller size
decreased embryo weight ( J:134861 )
• by E18.5, mutant weights are 60% of wild-type littermates

growth/size/body
decreased embryo size ( J:134861 )
• at E13.5, mutants can be distinguished by their smaller size
decreased embryo weight ( J:134861 )
• by E18.5, mutant weights are 60% of wild-type littermates

cardiovascular system

respiratory system
pulmonary hypoplasia ( J:134861 )
• E18.5-P0 animals have severely hypoplastic lungs but histological examination does not reveal any branching defect or other developmental abnormalities

hematopoietic system
increased B cell apoptosis ( J:134861 )
• mutant fetal livers display increased apoptosis specific to the B cell compartment without higher levels in non-B cells
• higher levels of apoptosis are not observed in other organs
abnormal B cell differentiation ( J:134861 )
• lethally irradiated mice transplanted with E14.5 mutant liver cells are found to have reduced percentages of pre-B cells and cells of later stages
decreased pre-B cell number ( J:134861 )
• fetal livers (E18.5) show a greatly reduced percentage and absolute number of pre-B cells

immune system
increased B cell apoptosis ( J:134861 )
• mutant fetal livers display increased apoptosis specific to the B cell compartment without higher levels in non-B cells
• higher levels of apoptosis are not observed in other organs
abnormal B cell differentiation ( J:134861 )
• lethally irradiated mice transplanted with E14.5 mutant liver cells are found to have reduced percentages of pre-B cells and cells of later stages
decreased pre-B cell number ( J:134861 )
• fetal livers (E18.5) show a greatly reduced percentage and absolute number of pre-B cells

cellular
increased B cell apoptosis ( J:134861 )
• mutant fetal livers display increased apoptosis specific to the B cell compartment without higher levels in non-B cells
• higher levels of apoptosis are not observed in other organs




Genotype
MGI:5662393
ht4
Allelic
Composition		 Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 B6.Cg-Mirc1tm1.2Tyj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
fused carpal bones ( J:223213 )
• 72% of mice exhibit fusion of the proximal carpal bones
brachyphalangia ( J:223213 )
• the fifth mesophalanx of the forelimb is shortened in E18.5 embryos

skeleton
fused carpal bones ( J:223213 )
• 72% of mice exhibit fusion of the proximal carpal bones
brachyphalangia ( J:223213 )
• the fifth mesophalanx of the forelimb is shortened in E18.5 embryos
lumbar vertebral transformation ( J:223213 )
• 46% of mice exhibit transformation of vertebra 26 (L6 to S1)




Genotype
MGI:5442701
ht5
Allelic
Composition		 Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
microcephaly ( J:188762 )
• the anterior-posterior axis of the skull is shortened and the skull shows an overall reduction in size
decreased body size ( J:188762 )
decreased body weight ( J:223213 )
• 4-5 week old mice weigh less than controls

limbs/digits/tail
brachyphalangia ( J:188762 )
• mesophalanx of the fifth finger is shorter
• however, other long bones in the hands are only marginally shorter than in wild-type and syndactyly is not observed

skeleton
brachyphalangia ( J:188762 )
• mesophalanx of the fifth finger is shorter
• however, other long bones in the hands are only marginally shorter than in wild-type and syndactyly is not observed

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Feingold syndrome DOID:0060464 OMIM:164280
OMIM:614326
 J:188762




Genotype
MGI:3796148
ht6
Allelic
Composition		 Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:134861 )
• newborn mice are slightly smaller than wild-type littermates




Genotype
MGI:4941217
cn7
Allelic
Composition		 Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:169047 )
• proximal outflow tract mesenchyme deficiency is more severe than in mutant mice wild-type for Mir17-92
• failure of fusion between proximal mesenchyme and outflow tract septum
abnormal truncus arteriosus septation ( J:169047 )
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• deficiency is more severe than in mutant mice wild-type for Mir17-92




Genotype
MGI:3796151
cx8
Allelic
Composition		 Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:134861 )
• embryos die before E15

cardiovascular system
blood vessel congestion ( J:134861 )
• at E13.5 and 14.5
atrial septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
ventricular septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
thin ventricular wall ( J:134861 )
• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular
increased apoptosis ( J:134861 )
• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences

homeostasis/metabolism
edema ( J:134861 )
• at E13.5 and 14.5




Genotype
MGI:3796152
cx9
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:134861 )
• embryos die before E15

cardiovascular system
atrial septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
ventricular septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
thin ventricular wall ( J:134861 )
• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular
increased apoptosis ( J:134861 )
• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences




Genotype
MGI:3796153
cx10
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable and fertile




Genotype
MGI:3796428
cx11
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3+
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable and fertile




Genotype
MGI:3796150
cx12
Allelic
Composition		 Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable and fertile




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory