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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mirc3tm1.1Tyj
targeted mutation 1.1, Tyler Jacks
MGI:3790969
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj involves: 129S4/SvJae * C57BL/6 * SJL MGI:3796138
cx2
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796150
cx3
Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796152
cx4
Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3+
Mirc1tm1.2Tyj/Mirc1+
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796428
cx5
Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796153
cx6
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796151


Genotype
MGI:3796138
hm1
Allelic
Composition
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous mice are recovered; lethality is suggested to be result of interference of the neomycin cassette with expression of the Mcm7 gene (positional effect)




Genotype
MGI:3796150
cx2
Allelic
Composition
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:3796152
cx3
Allelic
Composition
Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die before E15

cardiovascular system
• defective atrial and ventricular septation at E13.5 and E14.5
• defective atrial and ventricular septation at E13.5 and E14.5
• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular
• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences




Genotype
MGI:3796428
cx4
Allelic
Composition
Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3+
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:3796153
cx5
Allelic
Composition
Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:3796151
cx6
Allelic
Composition
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die before E15

cardiovascular system
• at E13.5 and 14.5
• defective atrial and ventricular septation at E13.5 and E14.5
• defective atrial and ventricular septation at E13.5 and E14.5
• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular
• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences

homeostasis/metabolism
• at E13.5 and 14.5





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory