mortality/aging
• no homozygous mice are recovered; lethality is suggested to be result of interference of the neomycin cassette with expression of the Mcm7 gene (positional effect)
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Allele Symbol Allele Name Allele ID |
Mirc3tm1.1Tyj targeted mutation 1.1, Tyler Jacks MGI:3790969 |
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Summary |
6 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no homozygous mice are recovered; lethality is suggested to be result of interference of the neomycin cassette with expression of the Mcm7 gene (positional effect)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos die before E15
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• defective atrial and ventricular septation at E13.5 and E14.5
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• defective atrial and ventricular septation at E13.5 and E14.5
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• ventricles are thinner than in wild-type at E13.5 and 14.5
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• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos die before E15
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• at E13.5 and 14.5
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• defective atrial and ventricular septation at E13.5 and E14.5
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• defective atrial and ventricular septation at E13.5 and E14.5
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• ventricles are thinner than in wild-type at E13.5 and 14.5
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• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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