Phenotypes associated with this allele

• Allele Symbol: Gad1^tm2Oba
• Allele Name: targeted mutation 2, Kunihiko Obata
• Allele ID: MGI:3793303
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gad1^tm2Oba/Gad1^tm2Oba Ptf1a^tm1.1(cre)Cvw/Ptf1a^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3805734

Genotype
MGI:3805734

cn1

• Allelic Composition: Gad1^tm2Oba/Gad1^tm2Oba; Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:134497 )

• at 6 weeks, rotarod performance is impaired compared to wild-type; mutants fall from rod more quickly than controls

abnormal gait ( J:134497 )

• gait is similar with almost equivalent stride length, but slightly larger stride width at 6 weeks of age

nervous system

abnormal nervous system morphology ( J:134497 )

• GABA level in mutant cerebellum is >44% of controls; largest reduction is observed at P7-P8 (reduced to 16%)

abnormal inhibitory postsynaptic currents ( J:134497 )

• frequency and amplitudes of spontaneous IPSCs in Purkinje cells are reduced compared to controls

• frequency and amplitudes of miniature IPSCs in Purkinje cells are significantly reduced compared to controls

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:134497 )

N • Langerhans islets are not affected in number or size

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:134497 )

N • at 6 weeks of age, blood insulin and glucose levels are not different from controls

craniofacial

craniofacial phenotype ( J:134497 )

N • mice do not develop cleft palate like Gad1 germline-null mice