Phenotypes associated with this allele

• Allele Symbol: Mapt^tm2(cre)Aha
• Allele Name: targeted mutation 2, Akihiro Harada
• Allele ID: MGI:3793311
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapt^tm2(cre)Aha/Mapt^tm2(cre)Aha	Not Specified	MGI:3805731
cn2	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Mapt^tm2(cre)Aha/?	involves: C57BL/6J	MGI:7489850
cn3	Smc3^tm1.1Toshi/Smc3^+ Mapt^tm2(cre)Aha/Mapt^+	involves: C57BL/6J	MGI:7489855

Genotype
MGI:3805731

hm1

• Allelic Composition: Mapt^tm2(cre)Aha/Mapt^tm2(cre)Aha
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:134499 )

N • mice are viable and fertile with no reduction in brain weight compared to wild-type; mice have normal lifespans

Genotype
MGI:7489850

cn2

• Allelic Composition: Smc3^tm1.1Toshi/Smc3^tm1.1Toshi; Mapt^tm2(cre)Aha/?
• Genetic Background: involves: C57BL/6J

mortality/aging

premature death ( J:242006 )

• mice die by 5 weeks of age

growth/size/body

decreased body size ( J:242006 )

• mice are significantly smaller than controls

postnatal growth retardation ( J:242006 )

Genotype
MGI:7489855

cn3

• Allelic Composition: Smc3^tm1.1Toshi/Smc3⁺; Mapt^tm2(cre)Aha/Mapt⁺
• Genetic Background: involves: C57BL/6J

behavior/neurological

increased anxiety-related response ( J:242006 )

♂ • in the novelty-induced hypophagia test, adult males show a significantly longer latency to drink milk in a novel, brightly lit cage as well as reduced milk consumption relative to controls, indicating increased anxiety

♂ • however, no significant differences are noted in the light/dark transition or marble-burying tests

nervous system

decreased CNS synapse formation ( J:242006 )

• at P21, Stat1 expression in the cortex is significantly higher than in controls