Phenotypes associated with this allele

• Allele Symbol: Gria1^tm5Rlh
• Allele Name: targeted mutation 5, Richard L Huganir
• Allele ID: MGI:3793349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria1^tm5Rlh/Gria1^tm5Rlh	involves: 129 * C57BL/6	MGI:3803305

Genotype
MGI:3803305

hm1

• Allelic Composition: Gria1^tm5Rlh/Gria1^tm5Rlh
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal associative learning ( J:135196 )

• mice fail to increase pokes of their nose into the prefered nose port upon a conditioned auditory cue while wild-type mice given the same training significantly increase the number of nose pokes by 5-fold

• the discrimination ratio between the conditioned and unconditioned noseport fails to be significantly different from chance

• the deficit in discriminating responding to the auditor cue is evident at the beginning of the test (i.e. does not result from differences in extinction rates)

• mice have no defects in normal food responses or overall locomotor activity