Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-EGFP/CETN2)3-4Jgg
• Allele Name: transgene insertion 3-4, Joseph G Gleeson
• Allele ID: MGI:3793421
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cetn2^tm1.1Wbae/Y Tg(CAG-EGFP/CETN2)3-4Jgg/0	involves: 129 * BALB/c * C57BL/6 * FVB/N	MGI:5661072
tg2	Tg(CAG-EGFP/CETN2)3-4Jgg/?	involves: BALB/c * C57BL/6	MGI:3793423

Genotype
MGI:5661072

cx1

• Allelic Composition: Cetn2^tm1.1Wbae/Y; Tg(CAG-EGFP/CETN2)3-4Jgg/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:211061 )

♂ • mice exhibit normal body weights and do not develop hydrocephalus, unlike males carrying the Cetn2^tm1.1Wbae allele

♂ • mice are rescued from the OSN ciliary trafficking defect, as shown by normal ciliary localizations of two major transmembrane signaling proteins (ACIII and CNGA2), and a peripheral membrane-associated protein

Genotype
MGI:3793423

tg2

• Allelic Composition: Tg(CAG-EGFP/CETN2)3-4Jgg/?
• Genetic Background: involves: BALB/c * C57BL/6

nervous system

nervous system phenotype ( J:91267 )

N • regions of cerebellum and ventricular zone show no increased levels of apoptosis or pyknotic nuclei compared to wild-type embryos

abnormal brain morphology ( J:91267 )

• intracellular GFP-expressing aggregates are observed exclusively in the adult brain in specific regions (T.G.G. personal comm.)