Allele Symbol Allele Name Allele ID |
Gata4tm1.2Sad targeted mutation 1.2, Stephen A Duncan MGI:3793424 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most mice die within a few hours of birth
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• mice exhibit a defect in the number and localization of muscle progenitors at E12.5
• at E14.5, differentiating myofibers are aberrant and myofibers and Pax7+ and MyoD+ muscle progenitors are absent in localized regions
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• the number of muscle progenitors is reduced by increased cell death and decreased proliferation
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• 100% of mice develop multiple hernias throughout the diaphragm
• overt herniation of liver through the diaphragm first occurs at E16.5
• size and location of hernias vary, with 68% forming in the dorsal lateral diaphragm (Bochdalek hernias) and 32% developing in the ventral diaphragm (Morgagni hernias)
• hernias occur only in muscle-associated regions and not in the central tendon
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• increase in the number of apoptotic cells in E12.5 embryos, many of which are present in regions that are abnormally devoid or muscle and consistently give rise to hernias
• decrease in the number of proliferative muscle progenitor cells in E12.5 embryos
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• mice exhibit low oxygen blood saturation
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• defects in the lung lobar structure
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• up to a 34% reduction in lung volume of lobes adjacent to hernias
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
congenital diaphragmatic hernia | DOID:3827 |
OMIM:142340 OMIM:222400 OMIM:610187 |
J:231793 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice do not develop diaphragmatic hernias
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N |
• mice do not exhibit lung defects
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• failure to form the heart tube is specific to the development of the cardiogenic mesoderm without effects on gastrulation or mesodermal migration
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• differentiated cardiomyocytes are not found in E7.5 or E8.5 embryos
• cardiac myocytes in E8.5 embryos fail to express smooth muscle actin, alpha myosin heavy chain, and alpha cardiac actin
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• the heart tube fails to form in E8.5 embryos
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• failure to form the heart tube is specific to the development of the cardiogenic mesoderm without effects on gastrulation or mesodermal migration
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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