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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata6tm3.1Sad
targeted mutation 3.1, Stephen A Duncan
MGI:3793425
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gata4tm1.2Sad/Gata4tm1.2Sad
Gata6tm3.1Sad/Gata6tm3.1Sad 		involves: 129 MGI:3803459


Genotype
MGI:3803459
cx1
Allelic
Composition		 Gata4tm1.2Sad/Gata4tm1.2Sad
Gata6tm3.1Sad/Gata6tm3.1Sad
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.2Sad mutation (0 available); any Gata4 mutation (36 available)
Gata6tm3.1Sad mutation (0 available); any Gata6 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiogenic mesoderm morphology ( J:135185 )
• failure to form the heart tube is specific to the development of the cardiogenic mesoderm without effects on gastrulation or mesodermal migration
abnormal fetal cardiomyocyte morphology ( J:135185 )
• differentiated cardiomyocytes are not found in E7.5 or E8.5 embryos
• cardiac myocytes in E8.5 embryos fail to express smooth muscle actin, alpha myosin heavy chain, and alpha cardiac actin
absent heart tube ( J:135185 )
• the heart tube fails to form in E8.5 embryos

embryo
abnormal cardiogenic mesoderm morphology ( J:135185 )
• failure to form the heart tube is specific to the development of the cardiogenic mesoderm without effects on gastrulation or mesodermal migration




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory