Phenotypes associated with this allele

• Allele Symbol: Tg(Igl-2MOPC315)1275Ust
• Allele Name: transgene insertion 1275, Ursula Storb
• Allele ID: MGI:3793466
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Igl-2MOPC315)1275Ust/?	C57BL/6-Tg(Igl-2MOPC315)1275Ust	MGI:3798835

Genotype
MGI:3798835

tg1

• Allelic Composition: Tg(Igl-2MOPC315)1275Ust/?
• Genetic Background: C57BL/6-Tg(Igl-2MOPC315)1275Ust

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:134666 )

• lambda 2 (Igl-2+) splenic B cells represent 65-79% of mu (Igh-6) positive B cells in 4 day old mice, decreasing to 48-56% by 70 days

• level of lambda 1 (Igl-1+) splenic B cells in transgenic mice is much lower than controls and remains low

• kappa (Igk+) splenic B cells are reduced to 33-39% of B cells in 4 day old mice

• the percentage if Igk+ cells increases with age, but does not reach the same level as controls (90%)

decreased immature B cell number ( J:134666 )

• slight decrease in number of IgM+ B cells in spleen

decreased IgM level ( J:134666 )

hematopoietic system

abnormal B cell morphology ( J:134666 )

• lambda 2 (Igl-2+) splenic B cells represent 65-79% of mu (Igh-6) positive B cells in 4 day old mice, decreasing to 48-56% by 70 days

• level of lambda 1 (Igl-1+) splenic B cells in transgenic mice is much lower than controls and remains low

• kappa (Igk+) splenic B cells are reduced to 33-39% of B cells in 4 day old mice

• the percentage if Igk+ cells increases with age, but does not reach the same level as controls (90%)

decreased immature B cell number ( J:134666 )

• slight decrease in number of IgM+ B cells in spleen

decreased IgM level ( J:134666 )