mortality/aging
• mean male death occurs at 40 days with signs of distress appearing 12 to 24 hours prior to death
• lethality is not background dependent and is observed in mice crossed to Mus castaneus, C57BL/6J and BXH2
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reproductive system
N |
• male mice that survive long enough to reproduce are fertile
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• moribund male mice exhibit underdeveloped seminal vesicles
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liver/biliary system
• moribund male mice exhibit slightly enlarged livers unlike in wild-type mice
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• moribund male mice exhibit microvesicular steatosis unlike in wild-type mice
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pale liver
(
J:79618
)
• moribund male mice exhibit salmon-colored liver with small, pale granules dispersed throughout the organ unlike in wild-type mice
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respiratory system
• in male mice just prior to death
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growth/size/body
• peripubescent male mice are smaller than normal
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• moribund male mice exhibit slightly enlarged livers unlike in wild-type mice
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adipose tissue
• moribund male mice exhibit underdeveloped fat pads surrounding the seminal vesicles
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behavior/neurological
• just prior to death, male mice exhibit extreme lethargy unlike in wild-type mice
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cardiovascular system
• just prior to death, male mice exhibit prominent blood vasculature of the extremities unlike in wild-type mice
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endocrine/exocrine glands
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• moribund male mice exhibit underdeveloped seminal vesicles
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integument
• just prior to death, male mice exhibit scruffy fur unlike in wild-type mice
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• just prior to death, male mice exhibit pinkish or purplish skin color unlike in wild-type mice
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