Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-TNNT2*I79N)9Jdp
• Allele Name: transgene insertion 9, James D Potter
• Allele ID: MGI:3793478
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-TNNT2*I79N)9Jdp/0	involves: C57BL/6 * SJL	MGI:5910054

Genotype
MGI:5910054

tg1

• Allelic Composition: Tg(Myh6-TNNT2*I79N)9Jdp/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart weight ( J:67284 )

• small decrease in heart weight to body weight ratio

• mice do not exhibit cardiac hypertrophy

abnormal myocardial fiber physiology ( J:67284 )

• papillary muscle fibers exhibit increased calcium sensitivity of steady state force development in both sedentary and exercised groups

• maximal steady state force developed by muscle fibers is decreased in both sedentary and exercised groups

• muscle fibers show an increased rate of force activation and moderately increased rate of relaxation

• cardiac muscle is less sensitive to acidic pH and shows a smaller decrease in calcium-sensitivity of force development indicating a loss of sensitivity to pH-induced shifts in calcium dependence of force

• large increase in the calcium sensitivity of the ATPase activity and force development in skinned fibers

mortality/aging

mortality/aging ( J:67284 )

N • mice exhibit normal survival and chronic swimming exercises do not affect survival