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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Celsr3tm2Agof
targeted mutation 2, Andre M Goffinet
MGI:3793629
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Celsr3tm1Agof/Celsr3tm2Agof
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd MGI:3795739
cn2
 		Celsr3tm1Agof/Celsr3tm2Agof
Tg(Nkx2-1-cre)1Wdr/0 		involves: 129P2/OlaHsd MGI:3795745
cn3
 		Celsr3tm1Agof/Celsr3tm2Agof
Emx1tm1(cre)Krj/Emx1+ 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:3795740
cn4
 		Celsr3tm1Agof/Celsr3tm2Agof
Tg(Gsx2-icre)1Kess/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3795744
cn5
 		Celsr3tm1Agof/Celsr3tm2Agof
Tg(Gsx2-icre)1Kess/0
Tg(Nkx2-1-cre)1Wdr/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3795746
cn6
 		Celsr3tm1Agof/Celsr3tm2Agof
Tg(mI56i-cre,EGFP)1Kc/0 		involves: 129P2/OlaHsd * FVB/N MGI:3795743


Genotype
MGI:3795739
cn1
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain internal capsule morphology ( J:134879 )
• despite normal expression in the dorsal thalamus, the three components of the internal capsule (corticothalamic axons, thalamocortical axons and subcerebral projections) are abnormal
• unlike in control mice, no thalamic fibers turn towards the striatum
• however, corticothalamic axons grow towards the ventral telencephalon




Genotype
MGI:3795745
cn2
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Tg(Nkx2-1-cre)1Wdr/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(Nkx2-1-cre)1Wdr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:134879 )
N
• the brain internal capsule develops normally




Genotype
MGI:3795740
cn3
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal anterior commissure morphology ( J:134879 )
• only diminutive bundles originating from the olfactory nuclei run caudally and turn but never cross the midline unlike in control mice (double heterozygotes)
abnormal brain internal capsule morphology ( J:134879 )
• subdural projections develop abnormally
• however, corticothalamic and thalamicortical axons are normal




Genotype
MGI:3795744
cn4
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Tg(Gsx2-icre)1Kess/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(Gsx2-icre)1Kess mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:134879 )
N
• the brain internal capsule develops normally




Genotype
MGI:3795746
cn5
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Tg(Gsx2-icre)1Kess/0
Tg(Nkx2-1-cre)1Wdr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(Gsx2-icre)1Kess mutation (1 available)
Tg(Nkx2-1-cre)1Wdr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:134879 )
N
• the brain internal capsule develops normally




Genotype
MGI:3795743
cn6
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain internal capsule morphology ( J:134879 )
• the thalamocortical axons aberrantly run through the pallidum and amygdala
• while corticofugal fibers cross the pallial-subpallial boundary and enter the lateral part of the basal forebrain, they fail to progress and spiral in a disordered manner
• both corticothalamic and thalamocortial axons are abnormal




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11/12/2024
MGI 6.24 		The Jackson Laboratory