Phenotypes associated with this allele

• Allele Symbol: Tg(H2-Aa)26Dim
• Allele Name: transgene insertion 26, Diane Mathis
• Allele ID: MGI:3793688
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(H2-Aa)26Dim/? Tg(H2-Ab1)62Dim/?	B6.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim	MGI:3799531
cx2	Tg(H2-Aa)26Dim/? Tg(H2-Ab1)62Dim/?	SJL.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim	MGI:3799532

Genotype
MGI:3799531

cx1

• Allelic Composition: Tg(H2-Aa)26Dim/?; Tg(H2-Ab1)62Dim/?
• Genetic Background: B6.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:110897 )

N • normal B and T cell populations as determined by flow cytometry

increased immunoglobulin level ( J:110897 )

• secondary, but not primary, antibody response is increased in response to the synthetic copolymer HGAL

abnormal antigen presentation via MHC class II ( J:110897 )

• increased efficiency of antigen presentation by splenocytes in response to KLH, however, in vivo antibody response to KLH as measured by ELISA is similar for control and transgenic

abnormal level of surface class II molecules ( J:110897 )

• class II A^k surface expression is increased 3-10X on transgenic splenocytes, however, class II A^b surface expression is the same in controls and transgenics

hematopoietic system

increased immunoglobulin level ( J:110897 )

• secondary, but not primary, antibody response is increased in response to the synthetic copolymer HGAL

Genotype
MGI:3799532

cx2

• Allelic Composition: Tg(H2-Aa)26Dim/?; Tg(H2-Ab1)62Dim/?
• Genetic Background: SJL.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim

immune system

immune system phenotype ( J:110897 )

N • normal B and T cell populations as determined by flow cytometry

abnormal level of surface class II molecules ( J:110897 )

• class II A^k surface expression is increased 3-10X on transgenic splenocytes