Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6*)131Lnwd
• Allele Name: transgene insertion 131, Leslie Leinwand
• Allele ID: MGI:3793714
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6*)131Lnwd/0	involves: C57BL/6 * CBA	MGI:5286085

Genotype
MGI:5286085

tg1

• Allelic Composition: Tg(Myh6*)131Lnwd/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:36522 )

• mutants exhibit abnormal cardiac histopathology, but do not exhibit cardiac hypertrophy at 12 weeks of age, indicating a less severe phenotype than Tg(Myh6*)140Lnwd/0 mice

cardiac hypertrophy ( J:31537 )

• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation

heart left ventricle hypertrophy ( J:31537 )

• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

growth/size/body

cardiac hypertrophy ( J:31537 )

• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation

heart left ventricle hypertrophy ( J:31537 )

• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

muscle

heart left ventricle hypertrophy ( J:31537 )

• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 14		DOID:0110320	OMIM:613251	J:31537