Phenotypes associated with this allele

• Allele Symbol: Foxp2^R552H
• Allele Name: Arg552His
• Allele ID: MGI:3793742
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxp2^R552H/Foxp2^R552H	involves: BALB/c * C3H/HeH	MGI:3795715
ht2	Foxp2^R552H/Foxp2^+	involves: BALB/c * C3H/HeH	MGI:3795716

Genotype
MGI:3795715

hm1

• Allelic Composition: Foxp2^R552H/Foxp2^R552H
• Genetic Background: involves: BALB/c * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:135404 )

• mice die at 3 to 4 weeks

nervous system

reduced cerebellar foliation ( J:135404 )

• decreased

small cerebellum ( J:135404 )

behavior/neurological

abnormal righting response ( J:135404 )

• mice exhibit a delay in the maturation of the righting reflex compared to in wild-type mice

abnormal vocalization ( J:135404 )

• unlike wild-type mice, isolated pups fail to produce high ultrasonic vocalization due to reduced arousal in isolation

• however, when newborns are raised above the ground they emit the normal range of vocalizations

• mice emit more clicks than wild-type mice when under distress

• interspersed ultrasound vocalizations have a lower sound pressure level and shorter duration than in wild-type mice

growth/size/body

slow postnatal weight gain ( J:135404 )

Genotype
MGI:3795716

ht2

• Allelic Composition: Foxp2^R552H/Foxp2⁺
• Genetic Background: involves: BALB/c * C3H/HeH

nervous system

reduced long-term depression ( J:135404 )

enhanced paired-pulse facilitation ( J:135404 )

behavior/neurological

abnormal motor learning ( J:135404 )

• motor skill learning on a running wheel is impaired compared to wild-type mice