All Phenotypes Plxna2<tm1Hfu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plxna2^tm1Hfu
targeted mutation 1, Hajime Fujisawa
MGI:3793763

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxna2^tm1Hfu/Plxna2^tm1Hfu	B6.Cg-Plxna2^tm1Hfu	MGI:3795748
hm2	Plxna2^tm1Hfu/Plxna2^tm1Hfu	involves: C57BL/6 * CBA	MGI:3795753
hm3	Plxna2^tm1Hfu/Plxna2^tm1Hfu	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5562537
cn4	Chat^tm2(cre)Lowl/Chat⁺ Plxna2^{tm1a(EUCOMM)Wtsi}/Plxna2^tm1Hfu	involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj	MGI:5562536
cx5	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795752
cx6	Plxna2^tm1Hfu/Plxna2⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795755
cx7	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5562540
cx8	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6b^tm1Hfu/Sema6b^tm1Hfu	involves: 129S/SvEv * C57BL/6 * CBA	MGI:4461291
cx9	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6b^tm1Hfu/Sema6b⁺	involves: 129S/SvEv * C57BL/6 * CBA	MGI:4461293
cx10	Plxna2^tm1Hfu/Plxna2^tm1Hfu Plxna4^tm1Hfu/Plxna4^tm1Hfu	involves: C57BL/6 * CBA	MGI:3795750

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu
Genetic Background	B6.Cg-Plxna2^tm1Hfu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:135421 )

• fibers invade the infrapyramidal region of Ca3c and the striatum pyramidalis of CA3ab rather than the suprapyramidal region

• in slice cocultures mossy fibers from homozygous mutant or wild-type dentate gyrus slices invade the infrapyramidal region or the stratum pyramidalis but not the suprapyramidal region of homozygous mutant CA3 slices

• however, paired pulse facilitation and long term potentiation are normal suggesting that mossy fiber synapses function normally

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuronal migration ( J:135408 )

• about 1/3 of labeled granule cells remain in the external granule layer 36 h after a BrdU injection

• the number of migrating cells and maximum migration distance are reduced in external granule layer explants

• in migrating granule cells the average distance between the centrosome and nucleus is increased and more variable

abnormal hippocampal mossy fiber morphology ( J:160509 )

• mossy fiber terminate at the proximal parts of the infrapyramidal region and stratum and fail to innervate into the suprapyramidal region unlike in wild-type mice

• mice lack a suprapyramidal bundle unlike wild-type mice

ectopic cerebellar granule cells ( J:135408 )

• about 40% of granule cells remain in the molecular layer in the adult cerebellum

• ectopic cells are still innervated by mossy fibers, neurite outgrowth from granule cells is normal and Purkinje cell differentiation is normal

vision/eye

vision/eye phenotype ( J:172268 )

N	• mice exhibit normal retinal stratification

cellular

decreased neuronal migration ( J:135408 )

• about 1/3 of labeled granule cells remain in the external granule layer 36 h after a BrdU injection

• the number of migrating cells and maximum migration distance are reduced in external granule layer explants

• in migrating granule cells the average distance between the centrosome and nucleus is increased and more variable

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:226501 )

• increased lymphatic branching complexity

• however, lymphatic endothelial cell numbers are normal

vision/eye

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

• On starburst amacrine cells retain asymmetric dendritic arbors; however, Off cells develop the normal radially symmetrical dendritic pattern

• dendritic arborization defects of On SACs in the x-y plane are independent of the stratification defects in the z plane

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• dendrites of both On and Off starburst amacrine cells fail to stratify appropriately

nervous system

abnormal dendrite morphology ( J:202884 )

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

• On starburst amacrine cells retain asymmetric dendritic arbors; however, Off cells develop the normal radially symmetrical dendritic pattern

• dendritic arborization defects of On SACs in the x-y plane are independent of the stratification defects in the z plane

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal neuron physiology ( J:202884 )

• in culture both SEMA6A- and SEMA6A+ starburst amacrine cells from the retina extend neurites across strips coated with recombinant SEMA6A protein

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Plxna2^{tm1a(EUCOMM)Wtsi}/Plxna2^tm1Hfu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Plxna2^{tm1a(EUCOMM)Wtsi} mutation (3 available); any Plxna2 mutation (130 available)
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

abnormal dendrite morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• disruption of the dendritic plexus organization of On but not Off SACs

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:135421 )

N	• unlike mice homozygous for Plxna2^tm1Hfu alone mossy fiber projection is essentially normal

abnormal hippocampal mossy fiber morphology ( J:160509 )

• the suprapyramidal bundle is slightly thinner than in wild-type mice

ectopic cerebellar granule cells ( J:135408 )

• the number of ectopic granule cells in the molecular layer is not significantly different from single homozygous mice

Allelic Composition	Plxna2^tm1Hfu/Plxna2⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

ectopic cerebellar granule cells ( J:135408 )

• in the molecular layer

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

abnormal dendrite morphology ( J:202884 )

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6b^tm1Hfu/Sema6b^tm1Hfu
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)
Sema6b^tm1Hfu mutation (0 available); any Sema6b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:160509 )

• mossy fibers initially grow into the proximal parts of the infrapyramidal region and stratum pyramidalis of CA3c and eventually invade proximal parts of the suprapyramidal region of CA3ab to form the thinner suprapyramidal bundle compared to in wild-type mice

• some mossy fibers directly invade the stratum radiatum and stratum oriens of the CA3c and sometimes grow into the stratum pyramidalis of CA1 unlike in wild-type mice

• the suprapyramidal bundle is thinner than in wild-type mice and Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg} double homozygotes

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6b^tm1Hfu/Sema6b⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:160509 )

• mossy fibers are restricted to proximal parts of the infrapyramidal region and stratum pyramidalis in most parts of CA3, except distal CA3ab, and form a very thin suprapyramidal bundle compared to in wild-type mice

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Plxna4^tm1Hfu/Plxna4^tm1Hfu
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)
Plxna4^tm1Hfu mutation (1 available); any Plxna4 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:135421 )

• mossy fibers are widely distributed in CA3 as in mice homozygous for Plxna4^tm1Hfu alone

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