Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(RARA*)Soc}
• Allele Name: targeted mutation 1, Shanthini Sockanathan
• Allele ID: MGI:3793772
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(RARA*)Soc/Gt(ROSA)26Sor^tm1(RARA*)Soc Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd	MGI:3795697
cn2	Gt(ROSA)26Sor^tm1(RARA*)Soc/Gt(ROSA)26Sor^tm1(RARA*)Soc Isl1^tm1(cre)Tmj/Isl1^+	involves: 129X1/SvJ	MGI:3795699

Genotype
MGI:3795697

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RARA*)Soc}/Gt(ROSA)26Sor^{tm1(RARA*)Soc}; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

telencephalon hypoplasia ( J:135403 )

• at E10.5, mice exhibit a 15% decrease in cell proliferation in the dorsal telencephalic progenitors due to slowed cell cycle progression compared to in control mice

• at E10.5, apoptosis is increased 5-fold in the pallium and 4-fold in the subpallium compared to in control mice

abnormal medial ganglionic eminence morphology ( J:135403 )

• Nkx2.1+ progenitor cells in the medial ganglionic eminence are mispecified

Genotype
MGI:3795699

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(RARA*)Soc}/Gt(ROSA)26Sor^{tm1(RARA*)Soc}; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129X1/SvJ

nervous system

decreased motor neuron number ( J:135403 )

• mice exhibit a 35% decrease in Lim1+/Islet2+ motor neurons compared to wild-type mice