All Phenotypes Tg(Osr1-cre)4Mrt MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Osr1-cre)4Mrt
transgene insertion 4, Gail R Martin
MGI:3793846

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467305
cn2	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467304
cn3	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N	MGI:5467306
cn4	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Osr1-cre)4Mrt/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5467307
cn5	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} Tg(Osr1-cre)4Mrt/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:6193618
cn6	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor⁺ Tg(Osr1-cre)4Mrt/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:6193619

Allelic Composition	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:192348 )

• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN

reproductive system

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:192348

Allelic Composition	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

reproductive system

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

Allelic Composition	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt mutation (1 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

Allelic Composition	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 50% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 50% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

reproductive system

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 50% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate adenocarcinoma		DOID:2526		J:234601

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor⁺ Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 40.9% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 40.9% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

increased malignant tumor incidence ( J:234601 )

• malignancy, with vascular invasion by neoplastic cells or local invasion of the tumor beyond the basement membrane into surrounding stromal tissues is seen in some mice

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

reproductive system

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 40.9% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate adenocarcinoma		DOID:2526		J:234601

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