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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Osr1-cre)4Mrt
transgene insertion 4, Gail R Martin
MGI:3793846
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ptentm2.1Ppp/Pten+
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N MGI:5467305
cn2
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N MGI:5467304
cn3
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Tg(Osr1-cre)4Mrt/0
involves: 129P2/OlaHsd * 129S1/Sv * FVB/N MGI:5467306
cn4
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Osr1-cre)4Mrt/0
involves: 129S1/Sv * 129X1/SvJ MGI:5467307
cn5
Gt(ROSA)26Sortm1(CAG-AR)Zsu/Gt(ROSA)26Sortm1(CAG-AR)Zsu
Tg(Osr1-cre)4Mrt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:6193618
cn6
Gt(ROSA)26Sortm1(CAG-AR)Zsu/Gt(ROSA)26Sor+
Tg(Osr1-cre)4Mrt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:6193619


Genotype
MGI:5467305
cn1
Allelic
Composition
Ptentm2.1Ppp/Pten+
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Spry1tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)
Spry1tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer
• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN
• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN
• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN

reproductive system
• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer
• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN
• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN
• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN

endocrine/exocrine glands
• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer
• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN
• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN
• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN




Genotype
MGI:5467304
cn2
Allelic
Composition
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)
Spry1tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate
• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

reproductive system
• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate
• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

neoplasm
• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN




Genotype
MGI:5467306
cn3
Allelic
Composition
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt mutation (1 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

reproductive system
• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

endocrine/exocrine glands
• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age




Genotype
MGI:5467307
cn4
Allelic
Composition
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

reproductive system
• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

endocrine/exocrine glands
• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN




Genotype
MGI:6193618
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-AR)Zsu/Gt(ROSA)26Sortm1(CAG-AR)Zsu
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-AR)Zsu mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 50% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm
• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 50% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

reproductive system
• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 50% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
prostate adenocarcinoma DOID:2526 J:234601




Genotype
MGI:6193619
cn6
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-AR)Zsu/Gt(ROSA)26Sor+
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-AR)Zsu mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age
• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 40.9% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 40.9% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions
• malignancy, with vascular invasion by neoplastic cells or local invasion of the tumor beyond the basement membrane into surrounding stromal tissues is seen in some mice
• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age
• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

reproductive system
• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age
• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 40.9% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
prostate adenocarcinoma DOID:2526 J:234601





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory