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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sfrp5tm1Aksh
targeted mutation 1, Akihiko Shimono
MGI:3793862
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Vangl2Lp/Vangl2+ 		involves: 129 * A * C57BL/6 * LPT/LeJ MGI:3795553
cx2
 		Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+ 		involves: 129 * A * C57BL/6 * LPT/LeJ MGI:3795555
cx3
 		Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+ 		involves: 129 * A * C57BL/6 * LPT/LeJ MGI:3795556
cx4
 		Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+ 		involves: 129 * C57BL/6 MGI:3795554
cx5
 		Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh 		involves: 129 * C57BL/6 MGI:3795557


Genotype
MGI:3795553
cx1
Allelic
Composition		 Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * A * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal rostral-caudal body axis extension ( J:135313 )
• mice exhibit an anterior-posterior elongation defect that is enhanced in the trunk relative to that observed in Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5+ mice
• at late head-fold stage, mice exhibit abnormal convergence and extension

nervous system




Genotype
MGI:3795555
cx2
Allelic
Composition		 Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * A * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:135313 )
• 62% of mice exhibit spina bifida

embryo
spina bifida ( J:135313 )
• 62% of mice exhibit spina bifida




Genotype
MGI:3795556
cx3
Allelic
Composition		 Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * A * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:135313 )
• 13% of mice exhibit spina bifida

embryo
spina bifida ( J:135313 )
• 13% of mice exhibit spina bifida




Genotype
MGI:3795554
cx4
Allelic
Composition		 Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo




Genotype
MGI:3795557
cx5
Allelic
Composition		 Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal rostral-caudal axis patterning ( J:135313 )
• mice exhibit more severe anterior-posterior axis defects than in Sfrp1tm1Aksh Sfrp2tm1Aksh homozygotes
open neural tube ( J:135313 )
• at E9.5
decreased somite size ( J:135313 )
• at E8.5, fused small somites are present
fused somites ( J:135313 )
• at E8.5, fused small somites are present

nervous system
open neural tube ( J:135313 )
• at E9.5

growth/size/body
embryonic growth retardation ( J:135313 )




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12/10/2024
MGI 6.24 		The Jackson Laboratory