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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tbc1d4tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3793866
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tbc1d4tm1Lex/Tbc1d4tm1Lex involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N MGI:5466292


Genotype
MGI:5466292
hm1
Allelic
Composition
Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic
Background
involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d4tm1Lex mutation (1 available); any Tbc1d4 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are recovered from mating heterozygotes

homeostasis/metabolism
• in random fed old male mice
• after 6 hour fasting in young and old male and female mice
• after 6 hour fasting in young male mice
• in female but not male mice
• glucose injection fails to increase glucose incorporation into glycogen
• however, basal levels are normal
• in male and female mice

adipose tissue
• decreased insulin-stimulated glucose uptake
• 1.7-fold increase in basal glucose uptake
• increased 1.5-fold in the brown adipose tissue of glucose-injected mice
• however, white adipose tissue from mice injected with saline and glucose exhibit normal glucose uptake

muscle
• decreased insulin-stimulated glucose uptake
• reduced glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus of saline-injected mice
• glucose injection fails to increase glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus unlike in wild-type mice
• however, basal glucose uptake is normal

cellular
• decreased insulin-stimulated glucose uptake
• 1.7-fold increase in basal glucose uptake
• increased 1.5-fold in the brown adipose tissue of glucose-injected mice
• however, white adipose tissue from mice injected with saline and glucose exhibit normal glucose uptake
• decreased insulin-stimulated glucose uptake
• reduced glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus of saline-injected mice
• glucose injection fails to increase glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus unlike in wild-type mice
• however, basal glucose uptake is normal





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory