mortality/aging
• fewer than expected mice are recovered from mating heterozygotes
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homeostasis/metabolism
• in random fed old male mice
• after 6 hour fasting in young and old male and female mice
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• after 6 hour fasting in young male mice
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• in female but not male mice
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• glucose injection fails to increase glucose incorporation into glycogen
• however, basal levels are normal
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• in male and female mice
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adipose tissue
• decreased insulin-stimulated glucose uptake
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• 1.7-fold increase in basal glucose uptake
• increased 1.5-fold in the brown adipose tissue of glucose-injected mice
• however, white adipose tissue from mice injected with saline and glucose exhibit normal glucose uptake
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muscle
• decreased insulin-stimulated glucose uptake
• reduced glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus of saline-injected mice
• glucose injection fails to increase glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus unlike in wild-type mice
• however, basal glucose uptake is normal
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cellular
• decreased insulin-stimulated glucose uptake
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• 1.7-fold increase in basal glucose uptake
• increased 1.5-fold in the brown adipose tissue of glucose-injected mice
• however, white adipose tissue from mice injected with saline and glucose exhibit normal glucose uptake
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• decreased insulin-stimulated glucose uptake
• reduced glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus of saline-injected mice
• glucose injection fails to increase glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus unlike in wild-type mice
• however, basal glucose uptake is normal
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