mortality/aging
• mice infected intracranially with mouse hepatitis virus strain J2.2v-1 (JHMV) show increased susceptibility to JHMV-induced death, with approximately 70% dying by 12 days post infection (dpi) compared to about 30% of wild-type mice
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immune system
• JHMV-infected mice show reduced numbers of CD4+ T cell within the brain at 5 dpi but levels return to normal at 7 and 12 dpi
• JHMV-infected mice show reduced numbers of virus-specific CD4+ T cells within the CNS at 7 dpi but increased numbers by 12 dpi
• JHMV-infected mice show decreased numbers of virus-specific CD4+ T cells isolated from spleens
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• JHMV-infected mice show reduced numbers of CD8+ T cells within the brains at 5 dpi but numbers are increased by 7 dpi and this increase in sustained to 12 dpi
• JHMV-infected mice show increased numbers of virus-specific CD8+ T cells within the CNS at 7 and 12 dpi
• however, numbers of virus-specific CD8+ T cells present in the spleen are similar to wild-type
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• macrophage infiltration is elevated in JHMV-infected mice at 7 and 12 dpi
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• CD4+ and CD8+ T cells show enhanced activation (CD62L-CD25+) states within the central nervous system (CNS)
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• JHMV virus-specific CD4+ T cells exhibit an approximate 2-fold increase in IFN-gamma production and CD8+ T cells show a more than 2.5-fold increase in IFN-gamma levels in response to peptide stimulation compared to wild-type mice
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• JHMV virus-specific T cells show a reduction in 1L-10 production
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• JHMV-infected mice show increased thickening of the meninges and increased perivascular cuffing indicating enhanced neuroinflammation
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• mice exhibit increased sensitivity to mouse hepatitis virus strain J2.2v-1 (JHMV)
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• mice infected intracranially with mouse hepatitis virus strain J2.2v-1 (JHMV) show increased susceptibility to JHMV-induced death, with approximately 70% dying by 12 days post infection (dpi) compared to about 30% of wild-type mice
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hematopoietic system
• JHMV-infected mice show reduced numbers of CD4+ T cell within the brain at 5 dpi but levels return to normal at 7 and 12 dpi
• JHMV-infected mice show reduced numbers of virus-specific CD4+ T cells within the CNS at 7 dpi but increased numbers by 12 dpi
• JHMV-infected mice show decreased numbers of virus-specific CD4+ T cells isolated from spleens
|
• JHMV-infected mice show reduced numbers of CD8+ T cells within the brains at 5 dpi but numbers are increased by 7 dpi and this increase in sustained to 12 dpi
• JHMV-infected mice show increased numbers of virus-specific CD8+ T cells within the CNS at 7 and 12 dpi
• however, numbers of virus-specific CD8+ T cells present in the spleen are similar to wild-type
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• macrophage infiltration is elevated in JHMV-infected mice at 7 and 12 dpi
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• CD4+ and CD8+ T cells show enhanced activation (CD62L-CD25+) states within the central nervous system (CNS)
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nervous system
• JHMV-infected mice show increased thickening of the meninges and increased perivascular cuffing indicating enhanced neuroinflammation
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astrocytosis
(
J:286951
)
• JHMV-infected mice show increased astrogliosis
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