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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ebi3Gt716Lex
gene trap 716, Lexicon Genetics
MGI:3793965
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ebi3Gt716Lex/Ebi3Gt716Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:6442003
cx2
Ebi3Gt716Lex/Ebi3Gt716Lex
Tg(DO11.10)10Dlo/0
involves: 129S5/SvEvBrd * BALB/c * C3H * C57BL/6 MGI:3795472


Genotype
MGI:6442003
hm1
Allelic
Composition
Ebi3Gt716Lex/Ebi3Gt716Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebi3Gt716Lex mutation (0 available); any Ebi3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice infected intracranially with mouse hepatitis virus strain J2.2v-1 (JHMV) show increased susceptibility to JHMV-induced death, with approximately 70% dying by 12 days post infection (dpi) compared to about 30% of wild-type mice

immune system
• JHMV-infected mice show reduced numbers of CD4+ T cell within the brain at 5 dpi but levels return to normal at 7 and 12 dpi
• JHMV-infected mice show reduced numbers of virus-specific CD4+ T cells within the CNS at 7 dpi but increased numbers by 12 dpi
• JHMV-infected mice show decreased numbers of virus-specific CD4+ T cells isolated from spleens
• JHMV-infected mice show reduced numbers of CD8+ T cells within the brains at 5 dpi but numbers are increased by 7 dpi and this increase in sustained to 12 dpi
• JHMV-infected mice show increased numbers of virus-specific CD8+ T cells within the CNS at 7 and 12 dpi
• however, numbers of virus-specific CD8+ T cells present in the spleen are similar to wild-type
• macrophage infiltration is elevated in JHMV-infected mice at 7 and 12 dpi
• CD4+ and CD8+ T cells show enhanced activation (CD62L-CD25+) states within the central nervous system (CNS)
• JHMV virus-specific CD4+ T cells exhibit an approximate 2-fold increase in IFN-gamma production and CD8+ T cells show a more than 2.5-fold increase in IFN-gamma levels in response to peptide stimulation compared to wild-type mice
• JHMV virus-specific T cells show a reduction in 1L-10 production
• JHMV-infected mice show increased thickening of the meninges and increased perivascular cuffing indicating enhanced neuroinflammation
• mice exhibit increased sensitivity to mouse hepatitis virus strain J2.2v-1 (JHMV) infection, showing elevated titers by 7 days post infection (dpi) which are reduced to below detection by 12 dpi indicating ability to control viral replication but showing increased disease severity with enhanced leukocyte infiltration and T cell activation and increased IFN-gamma secretion
• mice infected intracranially with mouse hepatitis virus strain J2.2v-1 (JHMV) show increased susceptibility to JHMV-induced death, with approximately 70% dying by 12 days post infection (dpi) compared to about 30% of wild-type mice

hematopoietic system
• JHMV-infected mice show reduced numbers of CD4+ T cell within the brain at 5 dpi but levels return to normal at 7 and 12 dpi
• JHMV-infected mice show reduced numbers of virus-specific CD4+ T cells within the CNS at 7 dpi but increased numbers by 12 dpi
• JHMV-infected mice show decreased numbers of virus-specific CD4+ T cells isolated from spleens
• JHMV-infected mice show reduced numbers of CD8+ T cells within the brains at 5 dpi but numbers are increased by 7 dpi and this increase in sustained to 12 dpi
• JHMV-infected mice show increased numbers of virus-specific CD8+ T cells within the CNS at 7 and 12 dpi
• however, numbers of virus-specific CD8+ T cells present in the spleen are similar to wild-type
• macrophage infiltration is elevated in JHMV-infected mice at 7 and 12 dpi
• CD4+ and CD8+ T cells show enhanced activation (CD62L-CD25+) states within the central nervous system (CNS)

nervous system
• JHMV-infected mice show increased thickening of the meninges and increased perivascular cuffing indicating enhanced neuroinflammation
• JHMV-infected mice show increased astrogliosis




Genotype
MGI:3795472
cx2
Allelic
Composition
Ebi3Gt716Lex/Ebi3Gt716Lex
Tg(DO11.10)10Dlo/0
Genetic
Background
involves: 129S5/SvEvBrd * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebi3Gt716Lex mutation (0 available); any Ebi3 mutation (12 available)
Tg(DO11.10)10Dlo mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following anti-CD3 antibody stimulation, differentiation into Th17 cells is increased compared to in wild-type mice
• following ovalbumin stimulation or infection with Listeriosis monocytogenes, Il-22 plasma levels are increased compared to in wild-type mice
• following ovalbumin stimulation or infection with Listeriosis monocytogenes
• following anti-CD3 antibody stimulation
• mice are resistant to infection with Listeriosis monocytogenes with a 45-fold less bacteria load in the spleen and a 150-fold less bacterial load in the liver after re-challenge compared to in similarly treated wild-type mice

homeostasis/metabolism
• following ovalbumin stimulation or infection with Listeriosis monocytogenes, Il-22 plasma levels are increased compared to in wild-type mice
• following ovalbumin stimulation or infection with Listeriosis monocytogenes

hematopoietic system
• following anti-CD3 antibody stimulation, differentiation into Th17 cells is increased compared to in wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory