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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smn1tm2Mrph
targeted mutation 2, Andrew Murphy
MGI:3794065
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smn1tm2Mrph/Smn1tm2Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5440966
hm2
 		Smn1tm2Mrph/Smn1tm2Mrph involves: 129S6/SvEvTac * C57BL/6NTac MGI:3794209
ht3
 		Smn1tm2Mrph/Smn1tm4(SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5440967
ht4
 		Smn1tm2Mrph/Smn1tm5(Smn1/SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5440968
ht5
 		Smn1tm2Mrph/Smn1tm6(SMN2)Mrph involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5440975


Genotype
MGI:5440966
hm1
Allelic
Composition		 Smn1tm2Mrph/Smn1tm2Mrph
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm2Mrph mutation (3 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:186987 )
• homozygotes are embryonic lethal




Genotype
MGI:3794209
hm2
Allelic
Composition		 Smn1tm2Mrph/Smn1tm2Mrph
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm2Mrph mutation (3 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:135422 )
• homozygotes die during development




Genotype
MGI:5440967
ht3
Allelic
Composition		 Smn1tm2Mrph/Smn1tm4(SMN2)Mrph
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm2Mrph mutation (3 available); any Smn1 mutation (87 available)
Smn1tm4(SMN2)Mrph mutation (3 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5440968
ht4
Allelic
Composition		 Smn1tm2Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm2Mrph mutation (3 available); any Smn1 mutation (87 available)
Smn1tm5(Smn1/SMN2)Mrph mutation (4 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5440975
ht5
Allelic
Composition		 Smn1tm2Mrph/Smn1tm6(SMN2)Mrph
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm2Mrph mutation (3 available); any Smn1 mutation (87 available)
Smn1tm6(SMN2)Mrph mutation (3 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
tail necrosis ( J:186987 )
• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age

integument
epidermal necrosis ( J:186987 )
• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory