Phenotypes associated with this allele

• Allele Symbol: Smn1^{tm4(SMN2)Mrph}
• Allele Name: targeted mutation 4, Andrew Murphy
• Allele ID: MGI:3794200
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smn1^tm4(SMN2)Mrph/Smn1^tm4(SMN2)Mrph	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440969
ht2	Smn1^tm2Mrph/Smn1^tm4(SMN2)Mrph	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440967
ht3	Smn1^tm4(SMN2)Mrph/Smn1^tm5(Smn1/SMN2)Mrph	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440970
ht4	Smn1^tm4(SMN2)Mrph/Smn1^tm6(SMN2)Mrph	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5440977

Genotype
MGI:5440969

hm1

• Allelic Composition: Smn1^{tm4(SMN2)Mrph}/Smn1^{tm4(SMN2)Mrph}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:186987 )

• homozygotes are embryonic lethal

Genotype
MGI:5440967

ht2

• Allelic Composition: Smn1^tm2Mrph/Smn1^{tm4(SMN2)Mrph}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

mortality/aging

embryonic lethality, complete penetrance ( J:186987 )

• embryonic lethal

Genotype
MGI:5440970

ht3

• Allelic Composition: Smn1^{tm4(SMN2)Mrph}/Smn1^{tm5(Smn1/SMN2)Mrph}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

mortality/aging

embryonic lethality, complete penetrance ( J:186987 )

• embryonic lethal

Genotype
MGI:5440977

ht4

• Allelic Composition: Smn1^{tm4(SMN2)Mrph}/Smn1^{tm6(SMN2)Mrph}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

limbs/digits/tail

tail necrosis ( J:186987 )

• onset of tail necrosis (tail swelling and shortening) occurs at 4 weeks of age

integument

epidermal necrosis ( J:186987 )

• mutants present with progressive necrosis of peripheral body parts beginning with the tail and moving toward the hindlimbs and then to the pinnae of the ears