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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm2Holl
targeted mutation 2, Monica Hollstein
MGI:3794646
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm2Holl/Trp53tm2Holl involves: 129P2/OlaHsd MGI:3803608
ht2
 		Trp53tm1Holl/Trp53tm2Holl involves: 129P2/OlaHsd MGI:3803611


Genotype
MGI:3803608
hm1
Allelic
Composition		 Trp53tm2Holl/Trp53tm2Holl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Holl mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:135505 )
• mouse embryonic fibroblasts (MEFs) generated from embryos immortalize at the same rate as wild-type MEFs




Genotype
MGI:3803611
ht2
Allelic
Composition		 Trp53tm1Holl/Trp53tm2Holl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (240 available)
Trp53tm2Holl mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:135505 )
• mouse embryonic fibroblasts (MEFs) generated from embryos immortalize at the same rate as wild-type MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory