Phenotypes associated with this allele

• Allele Symbol: Ppp4c^tm1.1Htn
• Allele Name: targeted mutation 1.1, Shinji Hirotsune
• Allele ID: MGI:3794743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppp4c^tm1.1Htn/Ppp4c^tm1.1Htn	involves: 129S6/SvEvTac * FVB/N	MGI:3794746

Genotype
MGI:3794746

cn1

• Allelic Composition: Ppp4c^tm1.1Htn/Ppp4c^tm1.1Htn
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal microtubule cytoskeleton morphology ( J:134682 )

• when transfected with cre recombinase, MEF cells have disorganized microtubule array in vitro

• the microtubule disorganization was restored by the expression of Ppp4c but not by Tbx6

• homozygous animals were viable and fertile

abnormal cell cycle ( J:134682 )

• when transfected with cre recombinase, MEF cells in culture were arrested in G2/M