Analysis Tools
growth/size/body
|
• homozygous pups weighed less than controls at 2 weeks of age, however eventually caught up with littermate control mice
|
homeostasis/metabolism
skin edema
(
J:135686
)
|
• subcutaneous edema are seen in embryos but not seen in adult
|
immune system
|
• lymphatic drainage function was impaired in embryos but not in adult
|
|
• disorganized and distended lymphatic vessels and lymphatic endothelial cells are found in mutant embryos
• collecting lymphatic vessels along both side of the ischiatic vein were missing and appeared tortuous, distended, or fused to form single vessels in adult homozygous mice
• vessel density of lymphatic vessels are reduced but average size and total area of lymphatic vessels are elevated
• the initial differentiation into lymphatic endothelial cells is normal
• number of lymphatic endothelial cells was normal
|
cardiovascular system
| N |
• blood vessels in embryos were unaffected
|
|
• lymphatic drainage function was impaired in embryos but not in adult
|
integument
skin edema
(
J:135686
)
|
• subcutaneous edema are seen in embryos but not seen in adult
|
