All Phenotypes Gsk3b<tm2Jrw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gsk3b^tm2Jrw
targeted mutation 2, James R Woodgett
MGI:3794785

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw	involves: 129 * C57BL/6 * CBA	MGI:4943266
cn2	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Tg(Ggt1-cre)M3Egn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	MGI:5429170
cn3	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Ins2-cre)23Herr/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	MGI:3802546

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Gsk3a^tm1Jrw mutation (0 available); any Gsk3a mutation (18 available)
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:164579 )

• mice develop hyperplastic lesions in the bladder unlike wild-type mice

Allelic Composition	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Tg(Ggt1-cre)M3Egn/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (113 available)
Tg(Ggt1-cre)M3Egn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:167190 )

N	• mutant kidneys are normal in terms of gross appearance, size, color, and glomerular and tubulointerstitial histology • kidney function, urine albumin excretion, and urine-concentrating ability remain normal

abnormal renal tubule morphology ( J:167190 )

• mice exhibit increased glycogen content in the renal cortical tubules, as shown by PAS staining and biochemical analysis

• EM revealed increased deposition of glycogen particles closely associated with tubules of smooth endoplasmic reticulum

abnormal proximal convoluted tubule morphology ( J:167190 )

• intense glycogen staining is primarily detected in the brush border of the renal tubules

homeostasis/metabolism

increased glycogen level ( J:167190 )

• mice exhibit increased glycogen accumulation in the renal cortical tubules

Allelic Composition	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Ins2-cre)23Herr/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (113 available)
Irs2^tm1Mfw mutation (1 available); any Irs2 mutation (37 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:135659 )

• fed blood glucose concentration were significantly reduced relative to that in Irs2^tm1Mfw homozygous mice, though remained slightly higher than normal control

increased circulating insulin level ( J:135659 )

• both fasting and fed insulin levels were higher than in wild-type mice similar to the level found in Irs2^tm1Mfw homozygous mice

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