Phenotypes associated with this allele

• Allele Symbol: Akt1^Gt1Pnt
• Allele Name: gene trap 1, Philip N Tsichlis
• Allele ID: MGI:3794786
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt1^Gt1Pnt/Akt1^Gt1Pnt	Not Specified	MGI:3803965
cx2	Akt1^Gt1Pnt/Akt1^Gt1Pnt Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804005
cx3	Akt1^Gt1Pnt/Akt1^Gt1Pnt Tg(MMTV-PyVT)634Mul/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804013

Genotype
MGI:3803965

hm1

• Allelic Composition: Akt1^Gt1Pnt/Akt1^Gt1Pnt
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:135903 )

• no abnormalities in T cell development are observed

Genotype
MGI:3804005

cx2

• Allelic Composition: Akt1^Gt1Pnt/Akt1^Gt1Pnt; Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

Genotype
MGI:3804013

cx3

• Allelic Composition: Akt1^Gt1Pnt/Akt1^Gt1Pnt; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly later than in mice carrying the transgene on a wild-type background

• mice harbor fewer and smaller hyperplastic foci at 8 and 12 weeks of age compared to transgenic mice on a wild-type background

• at later ages, the hyperplastic foci are smaller in size than in the transgenic controls

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• the percentage of proliferative cells found in early lesions of the mammary gland is half that found in transgenic mice on the wild-type background

• this decreased proliferation rate is not observed in later stages of tumor development

• both early lesions and advanced neoplasms have about double the percentage of apoptotic cells than is found in comparable tumors of transgenic mice on a wild-type background

• parenchymal metastases of breast adenocarcinomas are found in the lung

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly later than in mice carrying the transgene on a wild-type background

• mice harbor fewer and smaller hyperplastic foci at 8 and 12 weeks of age compared to transgenic mice on a wild-type background

• at later ages, the hyperplastic foci are smaller in size than in the transgenic controls

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• the percentage of proliferative cells found in early lesions of the mammary gland is half that found in transgenic mice on the wild-type background

• this decreased proliferation rate is not observed in later stages of tumor development

• both early lesions and advanced neoplasms have about double the percentage of apoptotic cells than is found in comparable tumors of transgenic mice on a wild-type background

• parenchymal metastases of breast adenocarcinomas are found in the lung

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly later than in mice carrying the transgene on a wild-type background

• mice harbor fewer and smaller hyperplastic foci at 8 and 12 weeks of age compared to transgenic mice on a wild-type background

• at later ages, the hyperplastic foci are smaller in size than in the transgenic controls

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• the percentage of proliferative cells found in early lesions of the mammary gland is half that found in transgenic mice on the wild-type background

• this decreased proliferation rate is not observed in later stages of tumor development

• both early lesions and advanced neoplasms have about double the percentage of apoptotic cells than is found in comparable tumors of transgenic mice on a wild-type background

• parenchymal metastases of breast adenocarcinomas are found in the lung