Analysis Tools
adipose tissue
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• adipocytes are smaller in size while the weight of adipose tissue remains the same
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homeostasis/metabolism
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• mice fed a high-fat diet for three weeks have almost half the serum levels of leptin compared to wild-type mice
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• free fatty acid levels in mice fed a high fat diet for 4 weeks are significantly lower than controls fed the same diet
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• triglyceride levels in mice fed a high fat diet for 4 weeks are significantly lower than controls fed the same diet
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• mice have higher tolerance to glucose challenge after being fed a high-fat diet for 8 weeks compared to wild-type mice fed the same diet
• mice have a third higher glucose uptake on a per gram bodyweight basis than in controls
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• mice fed a high fat diet for 11 weeks have higher drops in blood sugar upon insulin challenge compared to wild-type mice fed the same diet
• mice have a lower score than controls on the homeostasis model assessment measure of insulin sensitivity
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• mice fed a high-fat diet for 19 weeks have higher serum levels of adiponectin and increased expression of the adiponectin gene in their white adipose tissue
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