All Phenotypes Cldn15<tm1Sats> MGI Mouse

abnormal enterocyte morphology ( J:135596 )

• the tight junctions between enterocytes are decreased in number and poorly formed

abnormal enterocyte cell number ( J:135596 )

• the number but not the size of the villus epithelial cells is increased

• approximately 40 crypts are associated with each villus compared to 10 in the small intestine of wild-type mice

• the depth of crypts is 1.5- to 2 fold deeper than in wild-type mice

enlarged duodenum ( J:135596 )

• the diameter and length of the duodenum in adults is increased approximately 2-fold compared to wild-type mice

enlarged ileum ( J:135596 )

• the diameter and length of the ileum in adults is increased approximately 2-fold compared to wild-type mice

abnormal jejunum morphology ( J:135596 )

• the diameter and length of the jejunum in adults is increased approximately 2-fold compared to wild-type mice

• the size of villi are increased 2-fold compared to wild-type controls

• the number of villi found in the lumen of the upper small intestine is about double what is observed in controls

• the number of goblet cells found in the duodenum is slightly increased compared to controls

• the number of goblet cells found in the jejunum is slightly increased compared to controls

abnormal intestine physiology ( J:135596 )

• ion conductance of the distal portion of the jejunum is decreased by half compared to controls

abnormal enterocyte proliferation ( J:135596 )

• the proliferative zone of the epithelial cells within the crypts is expanded to about twice the length as found in wild-type mice

• a larger percentage of enterocytes in the crypts are actively proliferating