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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrgtm1.1Hish
targeted mutation 1.1, Hiromichi Ishikawa
MGI:3794897
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrgtm1.1Hish/Tcrgtm1.1Hish involves: 129P2/OlaHsd * C57BL/6 MGI:3803244
cx2
 		Tcratm1Mom/Tcratm1Mom
Tcrgtm1.1Hish/Tcrgtm1.1Hish 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3803245


Genotype
MGI:3803244
hm1
Allelic
Composition		 Tcrgtm1.1Hish/Tcrgtm1.1Hish
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrgtm1.1Hish mutation (0 available); any Tcrg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent gamma-delta T cells ( J:135597 )
• gamma-delta T cells are absent in the periphery including the gut IEL

immune system
absent gamma-delta T cells ( J:135597 )
• gamma-delta T cells are absent in the periphery including the gut IEL




Genotype
MGI:3803245
cx2
Allelic
Composition		 Tcratm1Mom/Tcratm1Mom
Tcrgtm1.1Hish/Tcrgtm1.1Hish
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mom mutation (6 available); any Tcra mutation (101 available)
Tcrgtm1.1Hish mutation (0 available); any Tcrg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:135597 )
• less macrophages are found in the lamina propia of the gut during colitis than in Tcratm1Mom homozygotes
colitis ( J:135597 )
• the colitis associated with Tcratm1Mom homozygotes is less severe in these mice with lower histological disease score and no anorectal prolapse
absent gamma-delta T cells ( J:135597 )
• gamma-delta T cells are absent in the periphery including the gut IEL
impaired neutrophil recruitment ( J:135597 )
• less numbers of neutrophils and monocytes are found in the lamina propia of the gut during colitis
• colonic extracts from mice have less ability to enhance migration of neutrophils compared to extracts from Tcratm1Mom homozygotes

hematopoietic system
impaired macrophage chemotaxis ( J:135597 )
• less macrophages are found in the lamina propia of the gut during colitis than in Tcratm1Mom homozygotes
absent gamma-delta T cells ( J:135597 )
• gamma-delta T cells are absent in the periphery including the gut IEL
impaired neutrophil recruitment ( J:135597 )
• less numbers of neutrophils and monocytes are found in the lamina propia of the gut during colitis
• colonic extracts from mice have less ability to enhance migration of neutrophils compared to extracts from Tcratm1Mom homozygotes

digestive/alimentary system
abnormal large intestine morphology ( J:135597 )
• the large intestine weight to body weight ratio at 28 weeks of age is 1.5 fold greater than in wild-type mice in these mice but is significantly less than in Tcratm1Mom homozygotes
colitis ( J:135597 )
• the colitis associated with Tcratm1Mom homozygotes is less severe in these mice with lower histological disease score and no anorectal prolapse

cellular
impaired macrophage chemotaxis ( J:135597 )
• less macrophages are found in the lamina propia of the gut during colitis than in Tcratm1Mom homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory