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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ace2tm1Hira
targeted mutation 1, Hiromi Rakugi
MGI:3794966
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Ace2tm1Hira/Y involves: 129S7/SvEvBrd * C57BL/6 MGI:3804205


Genotype
MGI:3804205
ot1
Allelic
Composition
Ace2tm1Hira/Y
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Hira mutation (0 available); any Ace2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• two-thirds of males die of congestive heart failure within 30 days of transverse aortic constriction (TAC) compared to one-third of wild-type males

growth/size/body
• two weeks after TAC, there is an increased gain in the heart weight to body weight ratio compared to wild-type males
• there is a significant increase in lung weight normalized to body weight two weeks after TAC compared to wild-type males receiving the same treatment

cardiovascular system
• TAC leads to pulmonary congestion in 46% of males compared to 13% of males in controls
• two weeks after TAC, there is an increased gain in the heart weight to body weight ratio compared to wild-type males
• two weeks after TAC, the left ventricle is much more dilated than in wild-type males receiving TAC
• left ventricle dimensions as measured by echocardiography confirm significant dilation
• perivascular fibrosis occurs in males two weeks after TAC but not in control males
• occurs in males two weeks after TAC while not occurring in controls
• ventricular contractility is decreased more so than in wild-type males two weeks after TAC with a fractional shortening of 31 compared to 36% in wild-type males
• dp/dt measurements are 15% lower than in wild-type males two weeks after TAC
• two-thirds of males die of congestive heart failure within 30 days of TAC compared to one-third of wild-type males

respiratory system
• TAC leads to pulmonary congestion in 46% of males compared to 13% of males in controls
• there is a significant increase in lung weight normalized to body weight two weeks after TAC compared to wild-type males receiving the same treatment

homeostasis/metabolism
• males have greater increases in angiotensin II levels in the heart tissue two weeks after TAC compared to similarly treated wild-type males
• mutant males had left ventricle levels of angiotensin II rise 7.5 fold after TAC while wild-type males only had a 5-fold rise in angiotensin II after TAC
• males have greater increases in angiotensin II levels in serum two weeks after TAC compared to similarly treated wild-type males

muscle
• ventricular contractility is decreased more so than in wild-type males two weeks after TAC with a fractional shortening of 31 compared to 36% in wild-type males
• dp/dt measurements are 15% lower than in wild-type males two weeks after TAC

cellular
• occurs in males two weeks after TAC while not occurring in controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory