About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Relatm1.2Gho
targeted mutation 1.2, Sankar Ghosh
MGI:3794988
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Relatm1.2Gho/Relatm1.2Gho involves: 129S6/SvEvTac * C57BL/6 MGI:3794991
cn2
 		Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 MGI:3794992


Genotype
MGI:3794991
hm1
Allelic
Composition		 Relatm1.2Gho/Relatm1.2Gho
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1.2Gho mutation (0 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:134684 )
• embryos die in utero between 11 and 16 dpc

liver/biliary system
increased hepatocyte apoptosis ( J:134684 )
• in homozygous mice at 15.5 dpc

cellular
increased hepatocyte apoptosis ( J:134684 )
• in homozygous mice at 15.5 dpc




Genotype
MGI:3794992
cn2
Allelic
Composition		 Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1.2Gho mutation (0 available); any Rela mutation (28 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:134684 )
• double homozygous mice die before 40 days
• the embryonic lethality seen among Relatm1.2Gho is completely rescued




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory