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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Relatm1.2Gho
targeted mutation 1.2, Sankar Ghosh
MGI:3794988
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Relatm1.2Gho/Relatm1.2Gho involves: 129S6/SvEvTac * C57BL/6 MGI:3794991
cn2
 		Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 MGI:3794992


Genotype
MGI:3794991
hm1
Allelic
Composition		 Relatm1.2Gho/Relatm1.2Gho
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1.2Gho mutation (0 available); any Rela mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:134684 )
• embryos die in utero between 11 and 16 dpc

liver/biliary system
increased hepatocyte apoptosis ( J:134684 )
• in homozygous mice at 15.5 dpc

cellular
increased hepatocyte apoptosis ( J:134684 )
• in homozygous mice at 15.5 dpc




Genotype
MGI:3794992
cn2
Allelic
Composition		 Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1.2Gho mutation (0 available); any Rela mutation (26 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:134684 )
• double homozygous mice die before 40 days
• the embryonic lethality seen among Relatm1.2Gho is completely rescued




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory