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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddx20tm1Yosa
targeted mutation 1, Yoel Sadovsky
MGI:3795148
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ddx20tm1Yosa/Ddx20tm1Yosa involves: 129/Sv * C57BL/6 MGI:3804255
ht2
Ddx20tm1Yosa/Ddx20+ involves: 129/Sv * C57BL/6 MGI:3804256


Genotype
MGI:3804255
hm1
Allelic
Composition
Ddx20tm1Yosa/Ddx20tm1Yosa
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx20tm1Yosa mutation (0 available); any Ddx20 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos fail to implant and do not progress past the 2 cell stage

embryo
• embryos do not progress past the 2 cell stage




Genotype
MGI:3804256
ht2
Allelic
Composition
Ddx20tm1Yosa/Ddx20+
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx20tm1Yosa mutation (0 available); any Ddx20 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• about 25% of follicles are devoid of oocytes, which is significantly higher than in wild-type females (about 5%)
• empty follicles are found at every stage of maturation
• ovaries are about 50% heavier than in wild-type controls
• there is no significant differences in weight of testes or adrenal glands

homeostasis/metabolism
• females have significantly less serum levels of ACTH in evenings and after 30 minutes of restraint stress compared to female controls

reproductive system
• about 25% of follicles are devoid of oocytes, which is significantly higher than in wild-type females (about 5%)
• empty follicles are found at every stage of maturation
• ovaries are about 50% heavier than in wild-type controls
• there is no significant differences in weight of testes or adrenal glands
• females spend more time in estrous (42%) than do female controls (27%)

growth/size/body
• ovaries are about 50% heavier than in wild-type controls
• there is no significant differences in weight of testes or adrenal glands





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory