About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brwd1Gt(AW0417)Wtsi
gene trap AW0417, Wellcome Trust Sanger Institute
MGI:3795157
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brwd1Gt(AW0417)Wtsi/Brwd1Gt(AW0417)Wtsi involves: 129P2/OlaHsd MGI:3795360
ht2
 		Brwd1Gt(AW0417)Wtsi/Brwd1repro5 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J MGI:3795359


Genotype
MGI:3795360
hm1
Allelic
Composition		 Brwd1Gt(AW0417)Wtsi/Brwd1Gt(AW0417)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brwd1Gt(AW0417)Wtsi mutation (0 available); any Brwd1 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell morphology ( J:136078 )
• sperm morphology is abnormal but not as pronounced as in Brwd1repro5 homozygotes
decreased male germ cell number ( J:136078 )
• epididymal sperm are reduced more than 3-fold compared to in wild-type mice
abnormal female meiosis ( J:136078 )
• oocytes exhibit a severe failure in the oocyte to embryo transition

cellular
abnormal male germ cell morphology ( J:136078 )
• sperm morphology is abnormal but not as pronounced as in Brwd1repro5 homozygotes
decreased male germ cell number ( J:136078 )
• epididymal sperm are reduced more than 3-fold compared to in wild-type mice
abnormal female meiosis ( J:136078 )
• oocytes exhibit a severe failure in the oocyte to embryo transition




Genotype
MGI:3795359
ht2
Allelic
Composition		 Brwd1Gt(AW0417)Wtsi/Brwd1repro5
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brwd1Gt(AW0417)Wtsi mutation (0 available); any Brwd1 mutation (106 available)
Brwd1repro5 mutation (0 available); any Brwd1 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
globozoospermia ( J:136078 )
• sperm have abnormally shaped heads and acrosomes
decreased male germ cell number ( J:136078 )
• epididymal sperm are reduced more than 5-fold compared to in wild-type mice

cellular
globozoospermia ( J:136078 )
• sperm have abnormally shaped heads and acrosomes
decreased male germ cell number ( J:136078 )
• epididymal sperm are reduced more than 5-fold compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory