Phenotypes associated with this allele

• Allele Symbol: Nkx6-3^tm1Shiv
• Allele Name: targeted mutation 1, Ramesh Shivdasani
• Allele ID: MGI:3795186
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx6-3^tm1Shiv/Nkx6-3^tm1Shiv	involves: 129S6/SvEvTac * C57BL/6	MGI:3804311

Genotype
MGI:3804311

hm1

• Allelic Composition: Nkx6-3^tm1Shiv/Nkx6-3^tm1Shiv
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal stomach enteroendocrine cell morphology ( J:136085 )

• there is about a 7-fold drop in the number of gastrin producing G cells in the antral gland units of the stomach

• there is also a 3-fold increase in the number of somatostatin producing cells in the antral glands

abnormal gastric parietal cell morphology ( J:136085 )

• mice over 5 months of age have a variable degree of parietal cell atrophy

abnormal gastric surface mucous cell morphology ( J:136085 )

• mice over 5 months of age have an occasional expansion of basal mucous cells

increased stomach pH ( J:136085 )

• mean levels of pH are 5.5 compared to 3.9 in wild-type mice

homeostasis/metabolism

decreased circulating gastrin level ( J:136085 )

• mean circulating gastrin levels are 37.7 ng/ml compared to 87.1 ng/ml in wild-type mice

endocrine/exocrine glands

abnormal stomach enteroendocrine cell morphology ( J:136085 )

• there is about a 7-fold drop in the number of gastrin producing G cells in the antral gland units of the stomach

• there is also a 3-fold increase in the number of somatostatin producing cells in the antral glands

abnormal gastric parietal cell morphology ( J:136085 )

• mice over 5 months of age have a variable degree of parietal cell atrophy