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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdpk1tm1Dral
targeted mutation 1, Dario R Alessi
MGI:3795190
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdpk1tm1Dral/Pdpk1tm1Dral B6.129P2-Pdpk1tm1Dral MGI:3804422


Genotype
MGI:3804422
hm1
Allelic
Composition
Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic
Background
B6.129P2-Pdpk1tm1Dral
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1Dral mutation (0 available); any Pdpk1 mutation (138 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• male and female mice are 35% smaller by weight at birth and through the first 15 weeks of life

endocrine/exocrine glands
• cells of the zona fasciculate are 40% smaller than in wild-type mice
• the percentage of islet cell volume to total pancreas volume in mice between 12-16 weeks of age is 1.2% compared to 0.8% in wild-type mice
• islet cell hypoplasia is noted in older male mice despite the hyperplasia observed in younger mice
• the percentage of islet cell volume to total pancreas volume in mice between 84-88 weeks of age is reduced compared to wild-type mice
• pancreas volume is 30% smaller compared to wild-type mice at 12-16 weeks of age but not in mice 84-88 weeks of age
• testis volume is 50% smaller than in wild-type males, which is a bigger reduction than the 20% reduction of other organs

homeostasis/metabolism
• mice have 3-fold or higher levels of circulating insulin than control mice
• higher insulin occurs in both mice between 12-16 weeks of age or mice over 1 year of age
• fasted mice do not have higher levels of insulin than in controls
• 1 or 6 hours after refeeding, insulin levels are back to being 3-fold higher than controls
• glucose challenge in fasted male and female mice aged 12-16 weeks results in significant increases in blood glucose levels over those observed in wild-type mice
• glucose intolerance is even greater in mice over one year in age
• injection of insulin leads to blunted drops in blood glucose levels compared to controls
• in mice over one year of age, insulin administration causes virtually no drops in blood glucose
• hyperinsulinemic-euglycemic clamp studies also reveal insulin resistance as 3-fold less glucose is needed to maintain euglucemia in mutant mice compared to controls

reproductive system
• testis volume is 50% smaller than in wild-type males, which is a bigger reduction than the 20% reduction of other organs

renal/urinary system
• kidney size is not reduced compared to wild-type mice despite the decrease in size of other organs and in total body weight

immune system
• spleen volume is reduced by 20% compared to wild-type

nervous system
• brain volume is reduced by 20% compared to wild-type

hematopoietic system
• spleen volume is reduced by 20% compared to wild-type





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory