Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}
• Allele Name: targeted mutation 5, Susan Dymecki
• Allele ID: MGI:3795199
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	En1^tm2(cre)Wrst/? Gt(ROSA)26Sor^tm5(CAG-EGFP,-lacZ)Dym/? Tg(Fev-flpe)1Dym/?	involves: 129S1/Sv * 129X1/SvJ	MGI:3804425
cn2	En1^tm2(cre)Wrst/? Gt(ROSA)26Sor^tm5(CAG-EGFP,-lacZ)Dym/? Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr Tg(Fev-flpe)1Dym/?	involves: 129S1/Sv * 129X1/SvJ	MGI:3804428
cn3	Egr2^tm2(cre)Pch/? Gt(ROSA)26Sor^tm5(CAG-EGFP,-lacZ)Dym/? Tg(Fev-flpe)1Dym/?	involves: 129S2/SvPas	MGI:3804426
cn4	Gt(ROSA)26Sor^tm5(CAG-EGFP,-lacZ)Dym/? Tg(Fev-flpe)1Dym/? Tg(Hoxa2-cre)1Dym/?	Not Specified	MGI:3804427

Genotype
MGI:3804425

cn1

• Allelic Composition: En1^tm2(cre)Wrst/?; Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}/?; Tg(Fev-flpe)1Dym/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:136096 )

• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem

• rhombomere-1 (r1) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising caudal to r1 are labeled by eGFP

Genotype
MGI:3804428

cn2

• Allelic Composition: En1^tm2(cre)Wrst/?; Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}/?; Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr; Tg(Fev-flpe)1Dym/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

abnormal rhombomere morphology ( J:136096 )

• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem

• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem

embryo

abnormal rhombomere morphology ( J:136096 )

• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem

• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem

Genotype
MGI:3804426

cn3

• Allelic Composition: Egr2^tm2(cre)Pch/?; Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}/?; Tg(Fev-flpe)1Dym/?
• Genetic Background: involves: 129S2/SvPas

normal phenotype

no abnormal phenotype detected ( J:136096 )

• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem

• rhombomere-3 (r3) rhombomere-5 (r5) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r3 or r5 are labeled by eGFP

Genotype
MGI:3804427

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}/?; Tg(Fev-flpe)1Dym/?; Tg(Hoxa2-cre)1Dym/?
• Genetic Background: Not Specified

normal phenotype

no abnormal phenotype detected ( J:136096 )

• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem

• rhombomere-2 (r2) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r2 are labeled by eGFP