Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Fev-flpe)1Dym transgene insertion 1, Susan Dymecki MGI:3795206 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal contextual fear conditioning and prepulse mediated inhibition of acoustic startle reflex
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• 5HT+ axon varicosities are enlarged compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising caudal to r1 are labeled by eGFP
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem
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• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-3 (r3) rhombomere-5 (r5) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r3 or r5 are labeled by eGFP
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heart rate is slower by 6-10% at P5 and P8
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• mice are less averse to open, brightly lit spaces compared with wild-type mice
• female mice exhibit decreased anxiety-related behaviors in open field, zero-maze, and light-dark tests compared with wild-type mice
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• pups are smaller than controls by 15-21% at P5 and P8
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• 5HT+ axon varicosities are enlarged compared to in wild-type mice
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• oxygen consumption is slightly but significantly lower at P5 and higher at P12
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• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12; deaths occur during the anoxic challenge
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• tidal volume is increased by 18-34% at P8 and P12
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• increase in baseline breathing variability at P5
• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12
• pups exposed to anoxia that die at P5 take 4 times longer to initiate gasping and 4 times longer to recover heart rate and eupneic breathing to 90% of baseline
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• 28% larger minute ventilation at P12
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sudden infant death syndrome | DOID:9007 |
OMIM:272120 |
J:231745 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-2 (r2) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r2 are labeled by eGFP
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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