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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Fev-flpe)1Dym
transgene insertion 1, Susan Dymecki
MGI:3795206
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
En1tm2(cre)Wrst/En1+
Tg(Fev-flpe)1Dym/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:4412291
cn2
En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
involves: 129S1/Sv * 129X1/SvJ MGI:3804425
cn3
En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
Tg(Fev-flpe)1Dym/?
involves: 129S1/Sv * 129X1/SvJ MGI:3804428
cn4
Egr2tm2(cre)Pch/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
involves: 129S2/SvPas MGI:3804426
cn5
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(Fev-flpe)1Dym/0
involves: 129S6/SvEvTac * FVB/N MGI:4412290
cn6
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Tg(Hoxa2-cre)1Dym/?
Not Specified MGI:3804427


Genotype
MGI:4412291
cn1
Allelic
Composition
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
En1tm2(cre)Wrst/En1+
Tg(Fev-flpe)1Dym/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Fev-flpe)1Dym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal contextual fear conditioning and prepulse mediated inhibition of acoustic startle reflex

nervous system
• 5HT+ axon varicosities are enlarged compared to in wild-type mice




Genotype
MGI:3804425
cn2
Allelic
Composition
En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Fev-flpe)1Dym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising caudal to r1 are labeled by eGFP




Genotype
MGI:3804428
cn3
Allelic
Composition
En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
Tg(Fev-flpe)1Dym/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Nkx2-2tm1Jlr mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Fev-flpe)1Dym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem

embryo
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem




Genotype
MGI:3804426
cn4
Allelic
Composition
Egr2tm2(cre)Pch/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm2(cre)Pch mutation (2 available); any Egr2 mutation (33 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Fev-flpe)1Dym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-3 (r3) rhombomere-5 (r5) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r3 or r5 are labeled by eGFP




Genotype
MGI:4412290
cn5
Allelic
Composition
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(Fev-flpe)1Dym/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Fev-flpe)1Dym mutation (0 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• heart rate is slower by 6-10% at P5 and P8

behavior/neurological
• mice are less averse to open, brightly lit spaces compared with wild-type mice
• female mice exhibit decreased anxiety-related behaviors in open field, zero-maze, and light-dark tests compared with wild-type mice

growth/size/body
• pups are smaller than controls by 15-21% at P5 and P8

nervous system
• 5HT+ axon varicosities are enlarged compared to in wild-type mice

homeostasis/metabolism
• oxygen consumption is slightly but significantly lower at P5 and higher at P12

mortality/aging
• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12; deaths occur during the anoxic challenge

respiratory system
• tidal volume is increased by 18-34% at P8 and P12
• increase in baseline breathing variability at P5
• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12
• pups exposed to anoxia that die at P5 take 4 times longer to initiate gasping and 4 times longer to recover heart rate and eupneic breathing to 90% of baseline
• pups have slower breathing than controls by 14% at P5 and P8
• 28% larger minute ventilation at P12

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sudden infant death syndrome DOID:9007 OMIM:272120
J:231745




Genotype
MGI:3804427
cn6
Allelic
Composition
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Tg(Hoxa2-cre)1Dym/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Fev-flpe)1Dym mutation (0 available)
Tg(Hoxa2-cre)1Dym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-2 (r2) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r2 are labeled by eGFP





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory