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Allele Symbol Allele Name Allele ID |
Tg(Itgax-TGFBR2)1Flv transgene insertion 1, Richard A Flavell MGI:3795208 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no effect on Eomes- NK cells
• Eomes+ NK cell number is increased
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• no effect on Eomes- NK cells
• Eomes+ NK cell number is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• size of dendritic cell (DC) compartment is normal in transgenic mice
• Flt3L treatment produces similar expansion of the DC compartment in mutants and controls
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• Flt3L induces a large degree of expansion of the NK cell compartment in transgenic mice relative to wild-type controls (20% vs 5%)
• natural killer (NK) cell homeostasis is dysregulated, with transgenic mice showing a higher frequency (10%) of NK cells in spleen vs controls (frequency = 3%)
• higher frequencies of NK cells are found in other organs, including liver and bone marrow, compared to controls
• in the presence of Il-15, transgenic splenocytes cultures show a 4-fold higher frequency of NK cells than cultured wild-type cells
• Tgfb (transforming growth factor beta) suppresses NK cell differentiation into Ifng-expressing cells in controls but has no effect in transgenic NK cells
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• by 3 weeks of age, mice 4-fold higher numbers of NK cells than controls; this is sustained throughout adult life; frequency of NK cells plateaus at 2 months of age
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• transgenic T lymphocytes isolated from draining lymph nodes of Leishmania infection exhibit a strong TH1 response by differentiation into Ifng-expressing CD4+ T cells, while control cells show a strong TH2 response without Ifng production
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• transgenic NK cells have 4-5 fold higher Ifng (interferon gamma) levels than control cells upon stimulation by different doses of Il-12; NK cells have higher intracellular Ifng levels after infection compared to control NK cells
• expression of Ifng is high and sustained in NK cells from transgenic mice
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• mice have increased resistance to infection by Leishmania major compared to wild-type controls
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• natural killer (NK) cell homeostasis is dysregulated, with transgenic mice showing a higher frequency (10%) of NK cells in spleen vs controls (frequency = 3%)
• higher frequencies of NK cells are found in other organs, including liver and bone marrow, compared to controls
• Flt3L induces a large degree of expansion of the NK cell compartment in transgenic mice relative to wild-type controls (20% vs 5%)
• in the presence of Il-15, transgenic splenocytes cultures show a 4-fold higher frequency of NK cells than cultured wild-type cells
• Tgfb (transforming growth factor beta) suppresses NK cell differentiation into Ifng-expressing cells in controls but has no effect in transgenic NK cells
|
|
• by 3 weeks of age, mice 4-fold higher numbers of NK cells than controls; this is sustained throughout adult life; frequency of NK cells plateaus at 2 months of age
|
|
• transgenic NK cells have 4-5 fold higher Ifng (interferon gamma) levels than control cells upon stimulation by different doses of Il-12; NK cells have higher intracellular Ifng levels after infection compared to control NK cells
• expression of Ifng is high and sustained in NK cells from transgenic mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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