Phenotypes associated with this allele

• Allele Symbol: Serpina10^tm1Gjb
• Allele Name: targeted mutation 1, George J Broze
• Allele ID: MGI:3795215
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpina10^tm1Gjb/Serpina10^tm1Gjb	involves: 129X1/SvJ * C57BL/6	MGI:3804658
cx2	F5^tm2Dgi/F5^tm2Dgi Serpina10^tm1Gjb/Serpina10^tm1Gjb	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3804660
cx3	F5^tm2Dgi/F5^+ Serpina10^tm1Gjb/Serpina10^tm1Gjb	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3804661

Genotype
MGI:3804658

hm1

• Allelic Composition: Serpina10^tm1Gjb/Serpina10^tm1Gjb
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:136102 )

• mice show increased mortality in a collagen/epinephrine-induced thromboembolism model, with 67% of mice dying of respiratory arrest within 5 minutes of collagen/epinephrine administration compared to 27% in wild-type mice

decreased survivor rate ( J:136102 )

• analysis of 385 progeny of heterozygote parents reveals only 20% of mice are homozygotes at 6 weeks of age, which is significantly lower than the expected 25% incidence

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:136102 )

• ferric chloride-induced carotid artery injury leads to 60% occlusion after 40 minutes, which is significantly higher than the 28% occlusion that occurs in wild-type mice

• increased mortality from pulmonary thromboembolism following collagen/epinephrine infusion

Genotype
MGI:3804660

cx2

• Allelic Composition: F5^tm2Dgi/F5^tm2Dgi; Serpina10^tm1Gjb/Serpina10^tm1Gjb
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

mortality/aging

decreased survivor rate ( J:136102 )

• no mice survive until 6 weeks of age

• only 4% of embryos out of an expected 25% live until E18.5 with this genotype, which is significantly different from the normal number of E18.5 embryos found with a Proz^tm1Gjb / Proz^tm1Gjb F5^tm2Dgi / F5^tm2Dgi genotype

• normal numbers of double homozygotes are found at E13.5

cardiovascular system

hemoperitoneum ( J:136102 )

• is often observed in E13.5 embryos

intracranial hemorrhage ( J:136102 )

• is often observed in E13.5 embryos

nervous system

intracranial hemorrhage ( J:136102 )

• is often observed in E13.5 embryos

Genotype
MGI:3804661

cx3

• Allelic Composition: F5^tm2Dgi/F5⁺; Serpina10^tm1Gjb/Serpina10^tm1Gjb
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

mortality/aging

decreased survivor rate ( J:136102 )

• only 18% of mice with this genotype are found at 6 weeks of age instead of the expected 25% based on Mendelian inheritance