Phenotypes associated with this allele

• Allele Symbol: Slc12a1^tm1Haca
• Allele Name: targeted mutation 1, Hayo Castrop
• Allele ID: MGI:3795217
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc12a1^tm1Haca/Slc12a1^tm1Haca	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:3843806

Genotype
MGI:3843806

hm1

• Allelic Composition: Slc12a1^tm1Haca/Slc12a1^tm1Haca
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating renin level ( J:135710 )

• when fed a high salt diet, mice exhibit lower plasma renin levels compared with similarly treated wild-type mice

• following administration of saline intravenously, mice exhibit lower renin plasma levels compared with similarly treated wild-type mice

abnormal mineral level ( J:135710 )

• at tubular perfusion rates of 6 or 15 nl/min, chloride ion concentration in the distal tubule is elevated compared to in wild-type mice

• at a low perfusion rate, absolute and fraction chloride ion absorption is higher compared to in wild-type mice

decreased urine osmolality ( J:135710 )

• ambient urine osmolarity is reduced compared to in wild-type mice

• however, urine osmolarity responds normally to water deprivation

renal/urinary system

decreased urine osmolality ( J:135710 )

• ambient urine osmolarity is reduced compared to in wild-type mice

• however, urine osmolarity responds normally to water deprivation

abnormal tubuloglomerular feedback response ( J:135710 )

• at a low perfusion rate, absolute and fraction chloride ion absorption and water absorption are higher compared to in wild-type mice

• tubuloglomerular feedback curve is right-shifted compared to in wild-type mice

• however, the maximum tubuloglomerular feedback is normal