Phenotypes associated with this allele

• Allele Symbol: Tsc2^tm1Kido
• Allele Name: targeted mutation 1, Yoshiaki Kido
• Allele ID: MGI:3795269
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tsc2^tm1Kido/Tsc2^tm1Kido	involves: 129S4/SvJae * C57BL/6	MGI:3797789
cn2	Tg(Ins2-cre)23Herr/0 Tsc2^tm1Kido/Tsc2^tm1Kido	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J	MGI:3797790

Genotype
MGI:3797789

hm1

• Allelic Composition: Tsc2^tm1Kido/Tsc2^tm1Kido
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:135811 )

• no abnormalities are detected in mice

Genotype
MGI:3797790

cn2

• Allelic Composition: Tg(Ins2-cre)23Herr/0; Tsc2^tm1Kido/Tsc2^tm1Kido
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J

homeostasis/metabolism

hypoglycemia ( J:135811 )

• in a fed state from 4 until 32 weeks of age

increased circulating glucose level ( J:135811 )

• after 36 week of age, mice exhibit increased plasma glucose levels compared to wild-type mice

• however, treatment of mice with rapamycin prevents the development of hyperglycemia

decreased circulating insulin level ( J:135811 )

• after 40 weeks of age

• however, treatment of mice with rapamycin prevents the decrease in plasma insulin levels

increased circulating insulin level ( J:135811 )

• at 12 weeks of age until 32 weeks

improved glucose tolerance ( J:135811 )

• at 8 weeks of age

increased insulin sensitivity ( J:135811 )

• at 8 weeks of age

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:135811 )

• at 40 weeks of age, islet cell density is decreased compared to in wild-type mice

increased pancreatic beta cell mass ( J:135811 )

• at 6 weeks of age, beta cell mass and size is increased compared to in wild-type mice

• at 40 weeks of age, beta cell mass decreases to lower than normal

• however, the number of beta cells is normal

• beta cell size is not decreased after 40 weeks of age

decreased pancreatic beta cell number ( J:135811 )

• at 40 weeks of age, beta cell number is decreased due to apoptosis

• however, treatment of mice with rapamycin prevents the decrease in beta cell mass observed at 40 weeks of age

pancreatic islet hyperplasia ( J:135811 )

• at 6 weeks of age

growth/size/body

decreased body weight ( J:135811 )

• after 48 weeks of age