About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr5a2tm1Sakl
targeted mutation 1, Steven A Kliewer
MGI:3795276
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nr5a2tm1Sakl/Nr5a2tm1Sakl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA MGI:3797770
cn2
 		Nr5a2tm1Sakl/Nr5a2tm1Sakl
Tg(Vil1-cre)997Gum/0 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL MGI:3797771


Genotype
MGI:3797770
cn1
Allelic
Composition		 Nr5a2tm1Sakl/Nr5a2tm1Sakl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a2tm1Sakl mutation (1 available); any Nr5a2 mutation (96 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

liver/biliary system
abnormal bile composition ( J:135822 )
• bile contains higher concentrations of tauromuricholic acids, taurochenodeoxycholic acid, alpha/omega muricholic acid, and beta-muricholic acid and lower concentrations of taurocholic acid and taurodeoxycholic acid compared to bile in wild-type mice




Genotype
MGI:3797771
cn2
Allelic
Composition		 Nr5a2tm1Sakl/Nr5a2tm1Sakl
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a2tm1Sakl mutation (1 available); any Nr5a2 mutation (96 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

digestive/alimentary system
digestive/alimentary phenotype ( J:135822 )
N
• unlike heterozygous null mice, villus length, crypt depth and intestinal proliferation are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory