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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gimap4tm1Jcbs
targeted mutation 1, Heinz Jacobs
MGI:3795278
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gimap4tm1Jcbs/Gimap4tm1Jcbs B6.129P2-Gimap4tm1Jcbs MGI:3797626


Genotype
MGI:3797626
hm1
Allelic
Composition		 Gimap4tm1Jcbs/Gimap4tm1Jcbs
Genetic
Background		 B6.129P2-Gimap4tm1Jcbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gimap4tm1Jcbs mutation (0 available); any Gimap4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:135744 )
• however, no differences in T cell development, selection, or activation are detected
• following induced cell death 2- to 4-fold more apoptotic cells and fewer membrane permeabilized dead cells are present compared to wild-type cells (no difference is detected in the number of live cells)

hematopoietic system
abnormal T cell physiology ( J:135744 )
• following induced cell death 2- to 4-fold more apoptotic cells and fewer membrane permeabilized dead cells are present compared to wild-type cells (no difference is detected in the number of live cells)
• however, no differences in T cell development, selection, or activation are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory