All Phenotypes Dicer1<tm1.1Mmk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dicer1^tm1.1Mmk
targeted mutation 1.1, Matthias Merkenschlager
MGI:3795355

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dicer1^tm1Mmk/Dicer1^tm1.1Mmk Cd79a^tm1(cre)Reth/Cd79a⁺	involves: BALB/c	MGI:3797392

Allelic Composition	Dicer1^tm1Mmk/Dicer1^tm1.1Mmk Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dicer1^tm1.1Mmk mutation (0 available); any Dicer1 mutation (96 available)
Dicer1^tm1Mmk mutation (0 available); any Dicer1 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immunoglobulin V(D)J recombination ( J:135783 )

• usage of Dh elements and N nucleotide insertion into Igkappa is increased compared to in wild-type mice

decreased B cell number ( J:135783 )

hematopoietic system

abnormal immunoglobulin V(D)J recombination ( J:135783 )

• usage of Dh elements and N nucleotide insertion into Igkappa is increased compared to in wild-type mice

decreased B cell number ( J:135783 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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