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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mirc1tm1Tyj
targeted mutation 1, Tyler Jacks
MGI:3795513
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mirc1tm1Tyj/Mirc1tm1Tyj
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA * SJL MGI:3796149


Genotype
MGI:3796149
cn1
Allelic
Composition
Mirc1tm1Tyj/Mirc1tm1Tyj
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1Tyj mutation (0 available); any Mirc1 mutation (6 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• pro-B cell apoptosis is observed in mice after induced cre expression
• viability of immature and mature B cells in the bone marrow is not affected by conditional ablation of Mirn17-92
• pro-B cells have normal D(H) to J(H) recombination, but V(H) to DJ(H) recombination is less efficient than in wild-type
• 2-month old mice injected with pI:pC to induce cre expression were found to have reduced numbers of pre-B cells in the bone marrow at 4 weeks after injection

immune system
• pro-B cell apoptosis is observed in mice after induced cre expression
• viability of immature and mature B cells in the bone marrow is not affected by conditional ablation of Mirn17-92
• pro-B cells have normal D(H) to J(H) recombination, but V(H) to DJ(H) recombination is less efficient than in wild-type
• 2-month old mice injected with pI:pC to induce cre expression were found to have reduced numbers of pre-B cells in the bone marrow at 4 weeks after injection

cellular
• pro-B cell apoptosis is observed in mice after induced cre expression
• viability of immature and mature B cells in the bone marrow is not affected by conditional ablation of Mirn17-92





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory