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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msx2tm1Yvla
targeted mutation 1, Yvan Lallemand
MGI:3795774
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msx2tm1Yvla/Msx2tm1Yvla involves: 129S2/SvPas * C57BL/6 * SJL MGI:3797242
cn2
 		Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+ 		involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI MGI:5297709
cn3
 		Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Yvla/Msx2tm1Yvla 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI MGI:5297713
cn4
 		Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Tg(Tek-cre)1Ywa/0 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL MGI:5297712
cn5
 		Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+ 		involves: 129S2/SvPas * 129S6/SvEvTac * NMRI MGI:5297710
cx6
 		Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Yvla/Msx2tm1Yvla 		involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:3797244
cx7
 		Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla 		involves: 129/Sv * BALB/c * C57BL/6 * SJL MGI:3797245


Genotype
MGI:3797242
hm1
Allelic
Composition		 Msx2tm1Yvla/Msx2tm1Yvla
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:136241 )
• mice are indistinguishable form wild-type mice




Genotype
MGI:5297709
cn2
Allelic
Composition		 Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx2tm1Bero mutation (1 available); any Msx2 mutation (23 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Taglntm2(cre)Yec mutation (1 available); any Tagln mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal artery morphology ( J:173525 )
• superficial temporal artery is more branched than in controls
abnormal carotid artery morphology ( J:173525 )
• at E11.5, carotid artery (CA) overbranching is observed
abnormal vertebral artery morphology ( J:173525 )
• vertebral artery (VA) caliber is increased relative to controls
vascular smooth muscle hypoplasia ( J:173525 )
• number of smooth muscle actin-positive cells in CA is half that observed in controls
intracranial aneurysm ( J:173525 )
• in the head, aneurysms are frequently observed
intracranial hemorrhage ( J:173525 )
• in the head, hemorrhages are frequently observed

muscle
vascular smooth muscle hypoplasia ( J:173525 )
• number of smooth muscle actin-positive cells in CA is half that observed in controls

nervous system
intracranial hemorrhage ( J:173525 )
• in the head, hemorrhages are frequently observed




Genotype
MGI:5297713
cn3
Allelic
Composition		 Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Yvla/Msx2tm1Yvla
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx1tm2.1(cre/ERT2)Bero mutation (2 available); any Msx1 mutation (18 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal carotid artery morphology ( J:173525 )
• increased carotid artery vessel diameter is observed
vascular smooth muscle hypoplasia ( J:173525 )
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle
vascular smooth muscle hypoplasia ( J:173525 )
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed




Genotype
MGI:5297712
cn4
Allelic
Composition		 Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rem mutation (1 available); any Msx1 mutation (18 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:173525 )
N
• carotid artery diamter and vascular smooth muscle cell (VSMC) are observed




Genotype
MGI:5297710
cn5
Allelic
Composition		 Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rem mutation (1 available); any Msx1 mutation (18 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Taglntm2(cre)Yec mutation (1 available); any Tagln mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal carotid artery morphology ( J:173525 )
• increased carotid artery section surface (increased vessel diameter) is observed
vascular smooth muscle hypoplasia ( J:173525 )
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle
vascular smooth muscle hypoplasia ( J:173525 )
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed




Genotype
MGI:3797244
cx6
Allelic
Composition		 Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Yvla/Msx2tm1Yvla
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal craniofacial morphology ( J:136241 )
• mice exhibit craniofacial malformations

limbs/digits/tail
abnormal limb development ( J:136241 )
• mice exhibit limb malformations

nervous system

growth/size/body
thoracoabdominoschisis ( J:136241 )
• thoracoabdominoschisis




Genotype
MGI:3797245
cx7
Allelic
Composition		 Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx2tm1Bero mutation (1 available); any Msx2 mutation (23 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial

digestive/alimentary system

growth/size/body
cleft palate ( J:136241 )
short snout ( J:136241 )




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory