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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pik3cbtm1Bvan
targeted mutation 1, Bart Vanhaesebroeck
MGI:3795849
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pik3cbtm1Bvan/Pik3cbtm1Bvan
Tg(Pf4-icre)Q3Rsko/0
involves: 129P2/OlaHsd MGI:4440894
cn2
Pik3cbtm1Bvan/Pik3cbtm1Bvan
Tg(Tek-cre)1Ywa/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3796333


Genotype
MGI:4440894
cn1
Allelic
Composition
Pik3cbtm1Bvan/Pik3cbtm1Bvan
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Bvan mutation (1 available); any Pik3cb mutation (152 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in response to low concentrations of thrombin and U46619, platelet aggregation is slight decreased compared with similarly treated wild-type cells
• in response to collagen and adenosine diphosphate, platelet aggregation is decreased compared with similarly treated wild-type cells
• in response to GPVI triggering by convulxin, platelet aggregation is abolished unlike similarly treated wild-type cells
• following FeCl3-induced injury, 90% of mice exhibit partial occlusion or fail to form thrombi unlike similarly treated wild-type mice

homeostasis/metabolism
• in response to low concentrations of thrombin and U46619, platelet aggregation is slight decreased compared with similarly treated wild-type cells
• in response to collagen and adenosine diphosphate, platelet aggregation is decreased compared with similarly treated wild-type cells
• in response to GPVI triggering by convulxin, platelet aggregation is abolished unlike similarly treated wild-type cells
• following FeCl3-induced injury, 90% of mice exhibit partial occlusion or fail to form thrombi unlike similarly treated wild-type mice




Genotype
MGI:3796333
cn2
Allelic
Composition
Pik3cbtm1Bvan/Pik3cbtm1Bvan
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Bvan mutation (1 available); any Pik3cb mutation (152 available)
Tg(Tek-cre)1Ywa mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• vascular development is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory