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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abcg4tm1Dgen
targeted mutation 1, Deltagen
MGI:3795864
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abcg4tm1Dgen/Abcg4tm1Dgen Not Specified MGI:4940634
cx2
 		Abcg1tm1Dgen/Abcg1tm1Dgen
Abcg4tm1Dgen/Abcg4+ 		involves: 129P2/OlaHsd MGI:4940639
cx3
 		Abcg1tm1Dgen/Abcg1+
Abcg4tm1Dgen/Abcg4tm1Dgen 		involves: 129P2/OlaHsd MGI:4940635
cx4
 		Abcg1tm1Dgen/Abcg1tm1Dgen
Abcg4tm1Dgen/Abcg4tm1Dgen 		involves: 129P2/OlaHsd MGI:4940638


Genotype
MGI:4940634
hm1
Allelic
Composition		 Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg4tm1Dgen mutation (0 available); any Abcg4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid level ( J:141549 )
• mice exhibit an increase brain lathosterol levels compared with wild-type mice




Genotype
MGI:4940639
cx2
Allelic
Composition		 Abcg1tm1Dgen/Abcg1tm1Dgen
Abcg4tm1Dgen/Abcg4+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (46 available)
Abcg4tm1Dgen mutation (0 available); any Abcg4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
abnormal lipid homeostasis ( J:141549 )
• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
abnormal lipid level ( J:141549 )
• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells

cellular
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells




Genotype
MGI:4940635
cx3
Allelic
Composition		 Abcg1tm1Dgen/Abcg1+
Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (46 available)
Abcg4tm1Dgen mutation (0 available); any Abcg4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
abnormal lipid homeostasis ( J:141549 )
• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
abnormal lipid level ( J:141549 )
• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells

cellular
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells




Genotype
MGI:4940638
cx4
Allelic
Composition		 Abcg1tm1Dgen/Abcg1tm1Dgen
Abcg4tm1Dgen/Abcg4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (46 available)
Abcg4tm1Dgen mutation (0 available); any Abcg4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
• HDL-dependent cholesterol efflux in astrocytes is decreased compared to in wild-type cells
abnormal lipid homeostasis ( J:141549 )
• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
abnormal cholesterol homeostasis ( J:141549 )
• cholesterol tracer transfer from astrocytes to neurons is decreased compared to in wild-type cells
abnormal lipid level ( J:141549 )
• mice exhibit a 2.4-fold increase in brain desmosterol levels compared with wild-type mice
• brain lanosterol, lathosterol, and 27-OH-cholesterol levels are increased by 1.9-, 1.5-, and 1.7-fold, respectively, compared with wild-type mice
• however, mice exhibit normal levels of brain cholesterol, 24(S)-OH-cholesterol, and plant sterol levels
• desmosterol levels are increased 4-fold in astrocytes compared to in wild-type cells

cellular
decreased cholesterol efflux ( J:141549 )
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
• HDL-dependent cholesterol efflux in astrocytes is decreased compared to in wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory